LSBio
Polyclonal Rabbit anti-Human CCL5 / RANTES Antibody (IHC, WB)

Polyclonal Rabbit anti-Human CCL5 / RANTES Antibody (IHC, WB)

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Antibody:Rabbit Polyclonal
Applications:Enzyme-Linked Immunosorbent Assay, Immunohistochemistry, Paraffin, Western Blot
Reactivity:Human
Format:Lyophilized
See all Human CCL5 / RANTES antibodies →
$523.00each
Catalog Number: LS-C42727-0.1

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Overview

Description
RANTES antibody LS-C42727 is an unconjugated rabbit polyclonal antibody to human RANTES (CCL5). Validated for ELISA, IHC and WB.
Application
ELISA, IHC-P, WB
Reactivity
Hu
Intended Use
Research Use Only
Guarantees
This antibody carries the LSBio 100% Guarantee. ✓
Category
Antibodies > Primary Antibodies > Polyclonal Antibodies
Alternative Names
Chemokine (C-C motif) ligand 5 | CCL5 | D17S136E | EoCP | T-cell specific protein p288 | SCYA5 | SISd | T cell-specific protein P228 | Beta-chemokine RANTES | C-C motif chemokine 5 | RANTES | SIS-delta | Small-inducible cytokine A5 | T-cell-specific protein RANTES | TCP228
Recommended Dilution: ELISA
0.5 - 2 ug/ml
UniProt Number
P13501
NCBI GenBank
NM_002985 | NP_002976.2
SwissProt
P13501

Target

Target
Human CCL5 / RANTES
Antigen Species
Human
Epitope
Recognizes human RANTES (regulated upon activation, normal T cell expressed and secreted), otherwise known as CCL5, a 68 amino acid CC- chemokine involved in T cell activation and cell recruitment, expressed by cytotoxic (CD8+) T cells (CTLs), macrophages, keratinocytes and endothelial cells. RANTES acts as a chemoattractant for monocytes, CD4+/CD45RO+ memory T cells, basophils and eosinophils, thorough binding to chemokine (C-C motif) receptor 1 (CCR1), CCR3 and CCR5. Both CCR3 and CCR5 are known co-receptors for the entry of HIV viruses into target cells and the binding of RANTES to CCR3 on CTLs has been shown to enhance HIV-1-specific cytotoxicity, whilst binding to CCR5 inhibits membrane fusion and hence HIV entry.
Gene Name
CCL5

Antibody

Host Species
Rabbit
Clonality
Polyclonal
Isotype
IgG

Immunogen

Immunogen
Recombinant human RANTES.
Immunogen Type
Recombinant Immunogen

Format

Conjugate/Label
Unconjugated
Format
Lyophilized
Formulation
PBS
Concentration
1 mg/mL
Preservative
No
Purification Method
Other

Storage & Handling

Storage Conditions
Store at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
Recommended Storage Buffer
PBS

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