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Polyclonal Rabbit anti-Human CASP4 / Caspase 4 Antibody (Concentrated, N-Terminus, IHC, WB)

Polyclonal Rabbit anti-Human CASP4 / Caspase 4 Antibody (Concentrated, N-Terminus, IHC, WB)

Primary AntibodyLSBio Guarantee
Antibody:Rabbit Polyclonal
Applications:Immunohistochemistry (general), Immunohistochemistry, Paraffin, Western Blot
Reactivity:Human
Format:Liquid
See all Human CASP4 / Caspase 4 antibodies →
$749.00each
Catalog Number: LS-C202788-0.1

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Overview

Description
Caspase 4 antibody LS-C202788 is an unconjugated rabbit polyclonal antibody to human Caspase 4 (CASP4) (N-Terminus). Validated for IHC and WB.
Application
IHC, IHC-P, WB
Reactivity
Hu
Intended Use
Research Use Only
Guarantees
This antibody carries the LSBio 100% Guarantee. ✓
Category
Antibodies > Primary Antibodies > Polyclonal Antibodies
Alternative Names
CASP-4 | Casp11 | CASP4 | Caspase 4 | Caspase-4 | Cysteine protease icerel-ii | ICE(rel)-II | ICE(rel)II | ICH-2 | Ich-3 | ICH2 | Protease ICH-2 | TX | Tx protease | Caspase 11 | ICEREL-II | Mih1/TX | Protease TX
UniProt Number
P49662
NCBI GenBank
NM_001225 | NP_001216.1
SwissProt
P49662

Target

Target
Human CASP4 / Caspase 4
Antigen Species
Human
Epitope
PS 298 recognizes an epitope within the N-terminal region (NT) of Caspase-4, otherwise known as ICH-2. Caspase-4, a member of the Caspase-1 subfamily of cysteine proteases, exists as an inactive pro-enzyme which undergoes proteolytic cleavage of its p30 precursor form, into smaller p20 and p10 subunits. The cellular localization of Caspase-4 on the Endoplasmic Reticulum (ER) membrane, has resulted in this protein becoming a focus of studies in which dysfunction or stress to the ER membrane is implicated, such as Alzheimer's disease and Ischemia (1, 3) and confirms the involvement of Caspase-4 as an instigator of cellular apoptosis. PS 298 detects a band of approximately 34 kD in Ramos cell lysates (predicted precursor MWT 31 kD).
Gene Name
CASP4

Antibody

Host Species
Rabbit
Clonality
Polyclonal

Immunogen

Immunogen
A 16 AA peptide from human Caspase-4 N-Terminus
Immunogen Type
Peptide

Format

Conjugate/Label
Unconjugated
Format
Liquid
Formulation
PBS, 0.02% Sodium Azide
Concentration
1 mg/mL
Preservative
Yes
Purification Method
Other

Storage & Handling

Storage Conditions
Store at 2-8°C.
Recommended Storage Buffer
PBS

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