LSBio
Polyclonal Rabbit anti-Human BECN1 / Beclin-1 Antibody (IHC, IF, WB)

Positive WB detected in:A549 whole cell lysate,Hela whole cell lysate,NIH/3T3 whole cell lysate,PC3 whole cell lysate,Raji whole cell lysate,SH-SY5Y whole cell lysate;All lanes:BECN1 antibody at 4?g/ml;Secondary;Goat polyclonal to rabbit IgG at 1/50000 dilution;Predicted band size: 52 KDa;Observed band size: 52,90 KDa;

Polyclonal Rabbit anti-Human BECN1 / Beclin-1 Antibody (IHC, IF, WB)

Primary AntibodyLSBio Guarantee
Antibody:Rabbit Polyclonal
Applications:Enzyme-Linked Immunosorbent Assay, Immunofluorescence, Immunohistochemistry (general), Western Blot
Reactivity:Human, Mouse
Format:Liquid
See all Human BECN1 / Beclin-1 antibodies →
$300.00each
Catalog Number: LS-C500779-50

For bulk orders or custom formulations:

Request a Quote

Overview

Description
Beclin-1 antibody LS-C500779 is an unconjugated rabbit polyclonal antibody to Beclin-1 (BECN1) from human. It is reactive with human and mouse. Validated for ELISA, IF, IHC and WB.
Application
ELISA, IF, IHC, WB
Reactivity
Hu, Ms
Intended Use
Research Use Only
Guarantees
This antibody carries the LSBio 100% Guarantee. ✓
Category
Antibodies > Primary Antibodies > Polyclonal Antibodies
Alternative Names
ATG6 | Beclin 1 | Beclin 1, autophagy related | Beclin1 | GT197 | Protein GT197 | VPS30 | Beclin-1 | BECN1
UniProt Number
Q14457
NCBI GenBank
NM_003766 | NP_003757.1
SwissProt
Q14457

Target

Target
Human BECN1 / Beclin-1
Antigen Species
Human
Epitope
Plays a central role in autophagy (PubMed:23184933). Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123, PubMed:20208530). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms. Involved in endocytosis (PubMed:25275521). Protects against infection by a neurovirulent strain of Sindbis virus (PubMed:9765397). May play a role in antiviral host defense.
Gene Name
BECN1

Antibody

Host Species
Rabbit
Clonality
Polyclonal
Isotype
IgG

Immunogen

Immunogen
Recombinant Human Beclin-1 protein (1-100AA)
Immunogen Type
Recombinant Immunogen

Format

Conjugate/Label
Unconjugated
Format
Liquid
Formulation
PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol.
Preservative
Yes
Purification Method
Protein G Affinity

Storage & Handling

Storage Conditions
Short term: -20°C; Long term: -80°C; Avoid freeze-thaw cycles.
Recommended Storage Buffer
PBS

Request SDS/MSDS

To request an SDS/MSDS form for this product, please contact our Technical Support department at: technical@vectorlabs.com.