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Polyclonal Rabbit anti-Human ATG14 Antibody (IHC, IF)

Immunohistochemistry of paraffin-embedded human pancreatic cancer using ATG14 Antibody at dilution of 1:100

Polyclonal Rabbit anti-Human ATG14 Antibody (IHC, IF)

Primary AntibodyLSBio Guarantee
Antibody:Rabbit Polyclonal
Applications:Enzyme-Linked Immunosorbent Assay, Immunofluorescence, Immunohistochemistry (general)
Reactivity:Human
Format:Liquid
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$300.00each
Catalog Number: LS-C501091-50

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Overview

Description
ATG14 antibody LS-C501091 is an unconjugated rabbit polyclonal antibody to human ATG14. Validated for ELISA, IF and IHC.
Application
ELISA, IF, IHC
Reactivity
Hu
Intended Use
Research Use Only
Guarantees
This antibody carries the LSBio 100% Guarantee. ✓
Category
Antibodies > Primary Antibodies > Polyclonal Antibodies
Alternative Names
Autophagy related 14 | Beclin 1-Interacting protein | KIAA0831 | ATG14 | ATG14L | BARKOR
UniProt Number
Q6ZNE5
NCBI GenBank
AB020638 | BAA74854.2
SwissProt
Q6ZNE5

Target

Target
Human ATG14
Antigen Species
Human
Epitope
Required for both basal and inducible autophagy. Determines the localization of the autophagy-specific PI3-kinase complex PI3KC3-C1 (PubMed:18843052, PubMed:19050071). Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosphatidylethanolamine (PubMed:19270696, PubMed:20713597). Promotes BECN1 translocation from the trans-Golgi network to autophagosomes (PubMed:20713597). Enhances PIK3C3 activity in a BECN1-dependent manner. Essential for the autophagy-dependent phosphorylation of BECN1 (PubMed:23878393). Stimulates the phosphorylation of BECN1, but suppresses the phosphorylation PIK3C3 by AMPK (PubMed:23878393). Binds to STX17-SNAP29 binary t-SNARE complex on autophagosomes and primes it for VAMP8 interaction to promote autophagosome-endolysosome fusion (PubMed:25686604). Modulates the hepatic lipid metabolism (By similarity).
Gene Name
ATG14

Antibody

Host Species
Rabbit
Clonality
Polyclonal
Isotype
IgG

Immunogen

Immunogen
Recombinant Human Beclin 1-associated autophagy-related key regulator protein (1-492AA)
Immunogen Type
Recombinant Immunogen

Format

Conjugate/Label
Unconjugated
Format
Liquid
Formulation
PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol.
Preservative
Yes
Purification Method
Protein G Affinity

Storage & Handling

Storage Conditions
Short term: -20°C; Long term: -80°C; Avoid freeze-thaw cycles.
Recommended Storage Buffer
PBS

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