LSBio
Polyclonal Rabbit anti-Human APOER2 / LRP8 Antibody (IF, WB)

Positive WB detected in:SH-SY5Y whole cell lysate,A549 whole cell lysate,U87 whole cell lysate;All lanes:LRP8 antibody at 3ug/ml;Secondary;Goat polyclonal to rabbit IgG at 1/50000 dilution;Predicted band size: 106,78,100,88 kDa;Observed band size: 106 kDa;

Polyclonal Rabbit anti-Human APOER2 / LRP8 Antibody (IF, WB)

Primary AntibodyLSBio Guarantee
Antibody:Rabbit Polyclonal
Applications:Enzyme-Linked Immunosorbent Assay, Immunofluorescence, Western Blot
Reactivity:Human
Format:Liquid
See all Human APOER2 / LRP8 antibodies →
$300.00each
Catalog Number: LS-C500926-50

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Overview

Description
LRP8 antibody LS-C500926 is an unconjugated rabbit polyclonal antibody to human LRP8 (APOER2). Validated for ELISA, IF and WB.
Application
ELISA, IF, WB
Reactivity
Hu
Intended Use
Research Use Only
Guarantees
This antibody carries the LSBio 100% Guarantee. ✓
Category
Antibodies > Primary Antibodies > Polyclonal Antibodies
Alternative Names
Apolipoprotein E receptor 2 | APOER2 | MCI1 | HSZ75190 | ApoE receptor 2 | LRP-8 | LRP8
UniProt Number
Q14114
NCBI GenBank
NM_004631 | NP_004622.2
SwissProt
Q14114

Target

Target
Human APOER2 / LRP8
Antigen Species
Human
Epitope
Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons. LRP8 has higher affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of the forebrain during embryonic brain development. Binds the endoplasmic reticulum resident receptor-associated protein (RAP). Binds dimers of beta 2-glycoprotein I and may be involved in the suppression of platelet aggregation in the vasculature. Highly expressed in the initial segment of the epididymis, where it affects the functional expression of clusterin and phospholipid hydroperoxide glutathione peroxidase (PHGPx), two proteins required for sperm maturation. May also function as an endocytic receptor.
Gene Name
LRP8

Antibody

Host Species
Rabbit
Clonality
Polyclonal
Isotype
IgG

Immunogen

Immunogen
Recombinant Human Low-density lipoprotein receptor-related protein 8 protein (131-332AA)
Immunogen Type
Recombinant Immunogen

Format

Conjugate/Label
Unconjugated
Format
Liquid
Formulation
PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol.
Preservative
Yes
Purification Method
Protein G Affinity

Storage & Handling

Storage Conditions
Short term: -20°C; Long term: -80°C; Avoid freeze-thaw cycles.
Recommended Storage Buffer
PBS

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