Immunofluorescent analysis of Hela cells using PLEKHO1 Antibody at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
PLEKHO1 / CKIP-1 Antibody
Primary AntibodyLSBio Guarantee
| Antibody: | Rabbit Polyclonal |
| Applications: | Enzyme-Linked Immunosorbent Assay, Immunofluorescence |
| Reactivity: | Human |
| Format: | Liquid |
$300.00each
Catalog Number: LS-C500859-50
Catalog Number: LS-C500859
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- Description
- CKIP-1 antibody LS-C500859 is an unconjugated rabbit polyclonal antibody to human CKIP-1 (PLEKHO1). Validated for ELISA and IF.
- Application
- ELISA, IF
- Reactivity
- Hu
- Intended Use
- Research Use Only
- Guarantees
- This antibody carries the LSBio 100% Guarantee. ✓
- Category
- Antibodies > Primary Antibodies > Polyclonal Antibodies
- Alternative Names
- CK2-interacting protein 1 | CKIP1 | JBP | OC120 | PLEKHO1 | C-Jun-binding protein | CKIP-1 | RP11-458I7.3
- UniProt Number
- Q53GL0
- NCBI GenBank
- NM_016274 | NP_057358.2
- SwissProt
- Q53GL0
Target
- Target
- Human PLEKHO1 / CKIP-1
- Antigen Species
- Human
- Epitope
- Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). Appears to target ATM to the plasma membrane. Appears to also inhibit tumor cell growth by inhibiting AKT-mediated cell-survival. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation.
- Gene Name
- PLEKHO1
Antibody
- Host Species
- Rabbit
- Clonality
- Polyclonal
- Isotype
- IgG
Immunogen
- Immunogen
- Recombinant Human Pleckstrin homology domain-containing family O member 1 protein (143-404AA)
- Immunogen Type
- Recombinant Immunogen
Format
- Conjugate/Label
- Unconjugated
- Format
- Liquid
- Formulation
- PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol.
- Concentration
- 3 mg/mL
- Preservative
- Yes
- Purification Method
- Protein G Affinity
Storage & Handling
- Storage Conditions
- Short term: -20°C; Long term: -80°C; Avoid freeze-thaw cycles.
- Recommended Storage Buffer
- PBS