PLAP / Alkaline Phosphatase Antibody (clone H17E2)
| Antibody: | Mouse Monoclonal |
| Applications: | Enzyme-Linked Immunosorbent Assay, Flow Cytometry, Immunohistochemistry (general), Immunohistochemistry, Frozen |
| Reactivity: | Human |
| Format: | Liquid |
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- Description
- Alkaline Phosphatase antibody LS-C44264 is an unconjugated mouse monoclonal antibody to human Alkaline Phosphatase (PLAP). Validated for ELISA, Flow and IHC. Cited in 4 publications.
- Application
- ELISA, FC, IHC, IHC-F
- Reactivity
- Hu
- Intended Use
- Research Use Only
- Guarantees
- This antibody carries the LSBio 100% Guarantee. ✓
- Category
- Antibodies > Primary Antibodies > Monoclonal Antibodies
- Alternative Names
- ALP | Alkaline phosphomonoesterase | ALPP | Glycerophosphatase | PALP | PLAP | PLAP-1 | Alp1 | Germ-cell alkaline phosphatase | Nagao isozyme | Regan isozyme
- Recommended Dilution: FC
- 10 ug/ml
- UniProt Number
- P05187
- NCBI GenBank
- NM_001632 | NP_001623.3
- SwissProt
- P05187
Target
- Target
- Human PLAP / Alkaline Phosphatase
- Antigen Species
- Human
- Epitope
- Recognizes human placental alkaline phosphate, a 67kD isoform expressed in trophoblast cells of normal human placenta, in seminomas and in ovarian carcinoma. The H17E2 antibody has been widely used in immunolocalization studies of germ cell tumors and may also be used in ELISA based assays for the measurement of soluble PLAP.
- Gene Name
- ALPP
Antibody
- Host Species
- Mouse
- Clonality
- Monoclonal
- Clone
- H17E2
- Isotype
- IgG1
Immunogen
- Immunogen
- Placental membrane.
- Immunogen Type
- Tissue Extract
Format
- Conjugate/Label
- Unconjugated
- Format
- Liquid
- Formulation
- PBS, 0.09% Sodium Azide
- Preservative
- Yes
- Purification Method
- Protein G Affinity
Storage & Handling
- Storage Conditions
- Short term: store at 4°C. Long term: aliquot and store at -20°C. Avoid freeze-thaw cycles.
- Recommended Storage Buffer
- PBS
Fusion of Epstein-Barr virus with epithelial cells can be triggered by v5 in addition to v6 and v8, and integrin binding triggers a conformational change in glycoproteins gHgL. Chesnokova LS, Hutt-Fletcher LM. Journal of virology. 2011;85:13214-23.
PubMed: 21957301 · PMC: PMC3233123
alpha v beta 3-integrin is a major sensor and activator of innate immunity to herpes simplex virus-1. Gianni T, Leoni V, Chesnokova LS, Hutt-Fletcher LM, Campadelli-Fiume G. Proceedings of the National Academy of Sciences of the United States of America. 2012 Nov;109:19792-7.
PubMed: 23150579 · PMC: PMC3511702
alpha v beta 6- and alpha v beta 8-integrins serve as interchangeable receptors for HSV gH/gL to promote endocytosis and activation of membrane fusion. Gianni T, Salvioli S, Chesnokova LS, Hutt-Fletcher LM, Campadelli-Fiume G. PLoS pathogens. 2013 Dec;9:e1003806.
PubMed: 24367260 · PMC: PMC3868510
Duration of simulated microgravity affects the differentiation of mesenchymal stem cells. Xue L, Li Y, Chen J. Molecular medicine reports. 2017;15:3011-3018.
PubMed: 28339035 · PMC: PMC5428749