PKM / Pyruvate Kinase, Muscle Antibody
Primary AntibodyLSBio Guarantee
| Antibody: | Rabbit Polyclonal |
| Applications: | Enzyme-Linked Immunosorbent Assay, Western Blot |
| Reactivity: | Human, Mouse, Rat |
| Format: | Liquid |
$402.00each
Catalog Number: LS-C413701-0.1
Catalog Number: LS-C413701
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- Description
- Pyruvate Kinase, Muscle antibody LS-C413701 is an unconjugated rabbit polyclonal antibody to Pyruvate Kinase, Muscle (PKM) from human. It is reactive with human, mouse and rat. Validated for ELISA and WB.
- Application
- ELISA, WB
- Reactivity
- Hu, Ms, Rt
- Intended Use
- Research Use Only
- Guarantees
- This antibody carries the LSBio 100% Guarantee. ✓
- Category
- Antibodies > Primary Antibodies > Polyclonal Antibodies
- Alternative Names
- p58 | PK3 | PKM | PKM2 | Pyruvate Kinase | Pyruvate kinase 2/3 | Pyruvate kinase, m1 | Pyruvate kinase, muscle | TCB | Tumor M2-PK | OIP-3 | OIP3 | Opa-interacting protein 3 | CTHBP | PK, muscle type | PK2 | Pyruvate kinase isozymes M1/M2 | Pyruvate kinase muscle isozyme | THBP1
- Recommended Dilution: ELISA
- 1:500 - 1:1000
- Recommended Dilution: WB
- 1:100 - 1:500
- UniProt Number
- P14618
- NCBI GenBank
- NM_002654 | NP_002645.3
- SwissProt
- P14618
Target
- Target
- Human PKM / Pyruvate Kinase, Muscle
- Antigen Species
- Human
- Epitope
- PKM2 is a glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP for generating ATP. There are 4 isoenzymes of pyruvate kinase in mammals (L, R, M1 and M2) encoded by 2 different genes: PKLR and PKM. The L and R isoenzymes are generated from the PKLR by differential splicing of RNA; the M1 and M2 forms are produced from the PKM gene by differential splicing. L type is the major isozyme in liver, R is found in red cells, M1 is the main form in muscle, heart and brain, and M2 is found in early fetal tissues as well as in most cancer cells. This antibody binds to both M1 and M2 isoforms of PKM.
- Gene Name
- PKM
Antibody
- Host Species
- Rabbit
- Clonality
- Polyclonal
Immunogen
- Immunogen
- KLH-conjugated synthetic peptide from the C-Terminus of human PKM2.
- Immunogen Type
- Synthetic Peptide (Linear)
Format
- Conjugate/Label
- Unconjugated
- Format
- Liquid
- Formulation
- PBS, pH 7.4, 0.09% sodium azide, 12.5% glycerol.
- Preservative
- Yes
- Purification Method
- Protein G Affinity
Storage & Handling
- Storage Conditions
- Store at -20°C. Avoid freeze-thaw cycles.
- Recommended Storage Buffer
- PBS