LSBio
PathPlus™ Recombinant Monoclonal Rabbit anti-Human TFF1 / pS2 Antibody (clone TFF1/2969R, aa50-100, IHC)

Human Foveolar Epithelium: Formalin-Fixed, Paraffin-Embedded (FFPE)

PathPlus™ Recombinant Monoclonal Rabbit anti-Human TFF1 / pS2 Antibody (clone TFF1/2969R, aa50-100, IHC)

Primary AntibodyLSBio Guarantee
Antibody:Rabbit Recombinant Monoclonal
Applications:Immunohistochemistry (general)
Reactivity:Human
Format:Liquid
See all TFF1 / pS2 antibodies →
$536.00each
Catalog Number: LS-B16301-100

For bulk orders or custom formulations:

Request a Quote

Overview

Description
PS2 antibody LS-B16301 is an unconjugated rabbit recombinant monoclonal antibody to human pS2 (TFF1) (aa50-100). Validated for IHC.
Application
IHC
Reactivity
Hu
Intended Use
Research Use Only
Guarantees
This product carries the LSBio 100% Guarantee. ✓
Category
Antibodies > Primary Antibodies > Recombinant Antibodies
Alternative Names
BCEI | D21S21 | HPS2 | PNR-2 | Polypeptide P1.A | Protein pS2 | PS2 | TFF1 | HP1.A | Trefoil factor 1
Recommended Dilution: IHC-P
1:100
UniProt Number
P04155
NCBI GenBank
NM_003225 | NP_003216.1
SwissProt
P04155

Target

Target
TFF1 / pS2
Antigen Species
Human
Specificity
It recognizes a polypeptide of 6.5 kDa , identified as pS2 estrogen-regulated protein. Its epitope is localized between aa57-84 of human pS2 protein. pS2 is a trefoil peptide. Trefoil peptides are protease resistant molecules secreted throughout the gut that play a role in mucosal healing. These peptides contain three intra-chain disulfide bonds, forming the trefoil motif, or P-domain. pS2 is known to form dimers and this dimerization is thought to play a role in its protective and healing properties. About 60% of breast carcinomas are positive for pS2. Staining is cytoplasmic, often with localization to the Golgi apparatus. pS2 is shown to be localized in normal stomach mucosa, gastric fluid, goblet cells in the colon and small intestine, and in ulcerations of the gastrointestinal tract. Several studies have shown that pS2 is primarily expressed in estrogen receptor-positive breast tumors and it may define a subset of estrogen-dependent tumors that displays an increased likelihood of response to endocrine therapy.
Epitope
This antibody recognizes a 6.5 kDa polypeptide identified as TFF1 / pS2 estrogen-regulated protein.
Gene Name
TFF1

Antibody

Host Species
Rabbit
Clonality
Recombinant Monoclonal
Clone
TFF1/2969R
Origin Species
Human

Immunogen

Immunogen
Synthetic peptide corresponding to the C-Terminus of human TFF1 / pS2.
Immunogen Type
Synthetic Peptide (Linear)

Format

Conjugate/Label
Unconjugated
Format
Liquid
Formulation
10 mM PBS, 0.05% BSA, 0.05% Sodium Azide
Concentration
200 µg/mL
Animal Free
No
Carrier-Free
No
Preservative
Yes
Purification Method
Protein A/G Affinity

Storage & Handling

Storage Conditions
Store at 2°C to 8°C for up to 2 years.
Recommended Storage Buffer
10 mM PBS

Request SDS/MSDS

To request an SDS/MSDS form for this product, please contact our Technical Support department at: technical@vectorlabs.com.