FGF21 Protein (Recombinant)
Catalog Number: LS-G27004
3 sizes / from $284.00
Expression System Escherichia coli (Prokaryotic)
Format: Lyophilized
Human Gastrointestinal Stromal Tumor: Formalin-Fixed, Paraffin-Embedded (FFPE)
PathPlus™ Recombinant Monoclonal Rabbit anti-Human ANO1 / DOG1 / TMEM16A Antibody (clone DG1/2564R, aa 2-101, IHC)
Primary AntibodyLSBio Guarantee
| Antibody: | Rabbit Recombinant Monoclonal |
| Applications: | Immunohistochemistry (general) |
| Reactivity: | Human |
| Format: | Liquid |
$536.00each
Catalog Number: LS-B16310-100
Catalog Number: LS-B16310
For bulk orders or custom formulations:
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- Description
- TMEM16A antibody LS-B16310 is an unconjugated rabbit recombinant monoclonal antibody to human TMEM16A (ANO1 / DOG1) (aa 2-101). Validated for IHC.
- Application
- IHC
- Reactivity
- Hu
- Intended Use
- Research Use Only
- Guarantees
- This product carries the LSBio 100% Guarantee. ✓
- Category
- Antibodies > Primary Antibodies > Recombinant Antibodies
- Alternative Names
- ANO1 | Oral cancer overexpressed 2 | Transmembrane protein 16A | ORAOV2 | Anoctamin-1 | DOG1 | TAOS2 | TMEM16A
- Recommended Dilution: Other
- 1:50
- UniProt Number
- Q5XXA6
- NCBI GenBank
- NM_018043 | NP_060513.5
- SwissProt
- Q5XXA6
Target
- Target
- ANO1 / DOG1 / TMEM16A
- Antigen Species
- Human
- Specificity
- Expression of DOG-1 protein is elevated in the gastrointestinal stromal tumors (GIST s), c-kit signaling-driven mesenchymal tumors of the GI tract. DOG-1 is rarely expressed in other soft tissue tumors, which, due to appearance, may be difficult to diagnose. Immunoreactivity for DOG-1 has been reported in 97.8 percent of scorable GIST s, including all c-kit negative GIST s. Overexpression of DOG-1 has been suggested to aid in the identification of GISTs, including Platelet-Derived Growth Factor Receptor Alpha mutants that fail to express c-kit antigen. The overall sensitivity of DOG1 and c-kit in GIST s is nearly identical: 94.4% vs. 94.7%.
- Epitope
- The expression of DOG1 is elevated in the gastrointestinal stromal tumors (GISTs), c-kit signaling-driven mesenchymal tumors of the GI tract. DOG1 is rarely expressed in other soft tissue tumors, which, due to appearance, may be difficult to diagnose. Immunoreactivity for DOG1 has been reported in 97.8 percent of scorable GIST s, including all c-kit negative GISTs. Overexpression of DOG1 has been suggested to aid in the identification of GISTs, including Platelet-Derived Growth Factor Receptor Alpha mutants that fail to express c-kit antigen. The overall sensitivity of DOG1 and c-kit in GIST s is nearly identical: 94.4% vs. 94.7%.
- Gene Name
- ANO1
Antibody
- Host Species
- Rabbit
- Clonality
- Recombinant Monoclonal
- Clone
- DG1/2564R
- Origin Species
- Human
Immunogen
- Immunogen
- Recombinant human DOG-1 protein fragment (aa 2-101). Antigen Molecular Weight: ~114 kDa
- Immunogen Type
- Recombinant Protein Fragment
Format
- Conjugate/Label
- Unconjugated
- Format
- Liquid
- Formulation
- 10 mM PBS, 0.05% BSA, 0.05% Sodium Azide
- Concentration
- 200 µg/mL
- Animal Free
- No
- Carrier-Free
- No
- Preservative
- Yes
- Purification Method
- Protein A/G Affinity
Storage & Handling
- Storage Conditions
- Store at 2°C to 8°C for up to 2 years.
- Recommended Storage Buffer
- 10 mM PBS
