LSBio
PathPlus™ Polyclonal Rabbit anti-Human NR0B2 Antibody (Ligand-binding Domain, IHC, IF)

Anti-NR0B2 antibody IHC of human liver, hepatocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

PathPlus™ Polyclonal Rabbit anti-Human NR0B2 Antibody (Ligand-binding Domain, IHC, IF)

Primary AntibodyLSBio Guarantee
Antibody:Rabbit Polyclonal
Applications:Immunohistochemistry (general)
Reactivity:Hamster, Human, Mouse, Non-Human Primate, Rabbit
Format:Liquid
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$403.00each
Catalog Number: LS-A5411-50

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Overview

Description
NR0B2 antibody LS-A5411 is an unconjugated rabbit polyclonal antibody to NR0B2 (Ligand-binding Domain) from human. It is reactive with human, mouse, hamster and other species. Validated for ICC, IF and IHC. Cited in 3 publications.
Application
IHC
Reactivity
Ham, Hu, Ms, NHP, Rb
Predicted Reactivity
Bovine, Mammal (Other), Rat
Intended Use
Research Use Only
Guarantees
This product carries the LSBio 100% Guarantee.
Category
Antibodies > Primary Antibodies > Polyclonal Antibodies
Alternative Names
Short heterodimer partner | SHP | NR0B2 | Nuclear receptor SHP | Orphan nuclear receptor SHP | Small heterodimer partner | SHP1 | shp
Recommended Dilution: IHC-P
4 µg/ml
UniProt Number
Q15466
SwissProt
Q15466

Target

Target
NR0B2
Antigen Species
Human
Specificity
Human NR0B2. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Epitope
Human NR0B2. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Gene Name
NR0B2

Antibody

Host Species
Rabbit
Clonality
Polyclonal

Immunogen

Immunogen
Synthetic 16 amino acid peptide from ligand-binding domain of human NR0B2. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Hamster, Rabbit (100%); Rat, Bovine, Bat (94%); Elephant, Panda, Horse, Pig, Opossum (88%); Dog (81%).
Immunogen Type
Synthetic Peptide (Linear)

Format

Conjugate/Label
Unconjugated
Format
Liquid
Formulation
PBS, 0.1% Sodium Azide
Concentration
1 mg/mL
Animal Free
No
Carrier-Free
Yes
Preservative
Yes
Purification Method
Affinity Purified

Storage & Handling

Storage Conditions
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Recommended Storage Buffer
PBS

Nuclear receptor SHP, a death receptor that targets mitochondria, induces apoptosis and inhibits tumor growth. Zhang Y, Soto J, Park K, Viswanath G, Kuwada S, Abel ED, Wang L. Molecular and cellular biology. 2010;30:1341-56.

PubMed: 20065042 · PMC: PMC2832505


Cellular distributions of molecules with altered expression specific to the tumor promotion process from the early stage in a rat two-stage hepatocarcinogenesis model. Takahashi M, Shibutani M, Woo GH, Inoue K, Fujimoto H, Igarashi K, Kanno J, Hirose M, Nishikawa A. Carcinogenesis. 2008 Nov;29:2218-26.

PubMed: 18586688


Epigenetic inhibition of nuclear receptor small heterodimer partner is associated with and regulates hepatocellular carcinoma growth. He N, Park K, Zhang Y, Huang J, Lu S, Wang L. Gastroenterology. 2008 Mar;134:793-802.

PubMed: 18325392

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