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PathPlus™ Polyclonal Rabbit anti-Human GLP1R / GLP-1 Receptor Antibody (N-Terminus, IHC)

Anti-GLP1R/GLP-1R/GLP-1 Receptor antibody IHC of human Adrenal, Pheochromocytoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

PathPlus™ Polyclonal Rabbit anti-Human GLP1R / GLP-1 Receptor Antibody (N-Terminus, IHC)

Primary AntibodyLSBio Guarantee
Antibody:Rabbit Polyclonal
Applications:Immunohistochemistry (general), Immunohistochemistry, Paraffin
Reactivity:Mouse
Format:Liquid
See all GLP1R / GLP-1 Receptor antibodies →
$470.00each
Catalog Number: LS-A1205-50

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Overview

Description
GLP-1 Receptor antibody LS-A1205 is an unconjugated rabbit polyclonal antibody to mouse GLP-1 Receptor (GLP1R) (N-Terminus). Validated for IHC. Cited in 8 publications.
Application
IHC, IHC-P
Reactivity
Ms
Intended Use
Research Use Only
Guarantees
This product carries the LSBio 100% Guarantee.
Category
Antibodies > Primary Antibodies > Polyclonal Antibodies
Alternative Names
GLP-1R | GLP1R | GLP-1-R | GLP-1 receptor | GLP-I receptor | Glp1 receptor
Recommended Dilution: IHC-P
20 µg/ml
UniProt Number
P43220
SwissProt
P43220

Target

Target
GLP1R / GLP-1 Receptor
Antigen Species
Human
Specificity
Human GLP1R. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except RUSC2 (44%).
Epitope
Human GLP1R. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except RUSC2 (44%).
Gene Name
GLP1R

Antibody

Host Species
Rabbit
Clonality
Polyclonal

Immunogen

Immunogen
Synthetic 16 amino acid peptide from N-Terminus extracellular domain of human GLP1R. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey (100%); Mouse, Bovine, Hamster, Elephant, Rabbit, Pig (94%); Rat, Dog, Bat, Panda (88%).
Immunogen Type
Synthetic Peptide (Linear)

Format

Conjugate/Label
Unconjugated
Format
Liquid
Formulation
PBS, 0.1% Sodium Azide
Concentration
1 mg/mL
Animal Free
No
Carrier-Free
Yes
Preservative
Yes
Purification Method
Affinity Purified

Storage & Handling

Storage Conditions
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Recommended Storage Buffer
PBS

Beneficial effects of exendin-4 on experimental polyneuropathy in diabetic mice. Himeno T, Kamiya H, Naruse K, Harada N, Ozaki N, Seino Y, Shibata T, Kondo M, Kato J, Okawa T, Fukami A, Hamada Y, Inagaki N, Seino Y, Drucker DJ, Oiso Y, Nakamura J. Diabetes. 2011;60:2397-406.

PubMed: 21810596 · PMC: PMC3161330


Pancreatic GLP-1 receptor activation is sufficient for incretin control of glucose metabolism in mice. Lamont BJ, Li Y, Kwan E, Brown TJ, Gaisano H, Drucker DJ. The Journal of clinical investigation. 2012;122:388-402.

PubMed: 22182839 · PMC: PMC3248276


GLP-1 Receptor Activation Indirectly Reduces Hepatic Lipid Accumulation But Does Not Attenuate Development of Atherosclerosis in Diabetic Male ApoE–/– Mice. Panjwani N, Mulvihill EE, Longuet C, Yusta B, Campbell JE, Brown TJ, Streutker C, Holland D, Cao X, Baggio LL, Drucker DJ. Endocrinology. 2013;154:127-39.

PubMed: 23183176


The Glucagon-Like Peptide-1 Receptor—or Not? Pyke C, Knudsen LB. Endocrinology. 2013;154:4-8.

PubMed: 23267050


Inhibition of monocyte adhesion to endothelial cells and attenuation of atherosclerotic lesion by a glucagon-like peptide-1 receptor agonist, exendin-4. Arakawa M, Mita T, Azuma K, Ebato C, Goto H, Nomiyama T, Fujitani Y, Hirose T, Kawamori R, Watada H. Diabetes. 2010 Apr;59:1030-7.

PubMed: 20068138 · PMC: PMC2844811


GLP-1R agonist liraglutide activates cytoprotective pathways and improves outcomes after experimental myocardial infarction in mice. Noyan-Ashraf MH, Momen MA, Ban K, Sadi AM, Zhou YQ, Riazi AM, Baggio LL, Henkelman RM, Husain M, Drucker DJ. Diabetes. 2009 Apr;58:975-83.

PubMed: 19151200 · PMC: PMC2661586


IRS-2 deficiency in macrophages promotes their accumulation in the vascular wall. Mita T, Azuma K, Goto H, Jin WL, Arakawa M, Nomiyama T, Suzuki R, Kubota N, Tobe K, Kadowaki T, Fujitani Y, Hirose T, Kawamori R, Watada H. Biochemical and biophysical research communications. 2011 Dec;415:545-50.

PubMed: 22074825


Glucagon-like peptide-1 modulates neurally evoked mucosal chloride secretion in guinea pig small intestine in vitro. Baldassano S, Wang GD, Mul[Character e8] F, Wood JD. American journal of physiology. Gastrointestinal and liver physiology. 2012 Feb;302:G352-8.

PubMed: 22075777 · PMC: PMC3287398

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