Human Thymus: Formalin-Fixed, Paraffin-Embedded (FFPE)

PathPlus™ KRT10 / CK10 / Cytokeratin 10 Antibody (clone KRT10/1990R)

Primary AntibodyLSBio Guarantee

Antibody:	Rabbit Recombinant Monoclonal
Applications:	Immunohistochemistry (general)
Reactivity:	Human
Format:	Liquid

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$536.00each

Catalog Number: LS-B16285-100

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Overview

Description: Cytokeratin 10 antibody LS-B16285 is an unconjugated rabbit recombinant monoclonal antibody to human Cytokeratin 10 (KRT10 / CK10). Validated for IHC.
Application: IHC
Reactivity: Hu
Intended Use: Research Use Only
Guarantees: This product carries the LSBio 100% Guarantee. ✓
Category: Antibodies > Primary Antibodies > Recombinant Antibodies
Alternative Names: BIE | BCIE | CK10 | Cytokeratin 10 | Cytokeratin-10 | EHK | Keratin-10 | KPP | KRT10 | Keratin 10 | CK-10 | K10
Recommended Dilution: IHC-P: 1:100
UniProt Number: P13645
NCBI GenBank: NM_000421 | NP_000412.3
SwissProt: P13645

Target

Target: KRT10 / CK10 / Cytokeratin 10
Antigen Species: Human
Specificity: This MAb recognizes a protein of 56.5 kDa , identified as cytokeratin 10 (CK10). CK10 is expressed in all suprabasal layers of the epidermis. In the epidermis, expression of CK10 strictly parallels the extent of differentiation; it is absent in the basal layer, appears in the first suprabasal layers and increases in concentration towards the granular layer. However, CK10 is rarely detected in early stages of vulvar squamous carcinomas (tumors less than 2 cm, clinical stage I) regardless of the tumor grade. In larger and more advanced tumors (greater than 2 cm, clinical stages II and III), CK10 is detected very frequently. Expression of CK10 is related to maturation of malignant keratinocytes, being preferentially detected in more-differentiated parts.
Epitope: This MAb recognizes a protein of 56.5 kDa , identified as cytokeratin 10 (CK10). CK10 is expressed in all suprabasal layers of the epidermis. In the epidermis, expression of CK10 strictly parallels the extent of differentiation; it is absent in the basal layer, appears in the first suprabasal layers and increases in concentration towards the granular layer. However, CK10 is rarely detected in early stages of vulvar squamous carcinomas (tumors less than 2 cm, clinical stage I) regardless of the tumor grade. In larger and more advanced tumors (greater than 2 cm, clinical stages II and III), CK10 is detected very frequently. Expression of CK10 is related to maturation of malignant keratinocytes, being preferentially detected in more-differentiated parts.
Gene Name: KRT10