Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE)

PathPlus™ FOXA1 Antibody (aa372-472, clone rFOXA1/1515)

Primary AntibodyLSBio Guarantee

Antibody:	Mouse Recombinant Monoclonal
Applications:	Immunohistochemistry (general)
Reactivity:	Human
Format:	Liquid

$536.00each

Catalog Number: LS-B16245-100

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Overview

Description: FOXA1 antibody LS-B16245 is an unconjugated mouse recombinant monoclonal antibody to human FOXA1 (aa372-472). Validated for IHC.
Application: IHC
Reactivity: Hu
Intended Use: Research Use Only
Guarantees: This product carries the LSBio 100% Guarantee. ✓
Category: Antibodies > Primary Antibodies > Recombinant Antibodies
Alternative Names: Forkhead box A1 | Forkhead box protein A1 | HNF-3-alpha | HNF-3A | TCF-3A | TCF3A | FOXA1 | HNF3A | Transcription factor 3A
Recommended Dilution: IHC-P: 1:50
UniProt Number: P55317
NCBI GenBank: NM_004496 | NP_004487.2
SwissProt: P55317

Target

Target: FOXA1
Antigen Species: Human
Specificity: The transcription factor Forkhead-box A1 (FOXA1), also known as hepatocyte nuclear factor 3-alpha, is a member of the FOX class of transcription factors. HNF-1 (alpha and beta), HNF-3 (alpha, beta and gamma), HNF-4 (alpha and gamma), and HNF-6 compose, in part, a homeoprotein family designated the hepatocyte nuclear factor family. The various HNF-1 isoforms regulate transcription of genes in the liver as well as in other tissues such as kidney, small intestine and thymus. FOXA1 is expressed in normal breast ductal epithelium and other epithelium in different organs, such as lung, pancreas, bladder, prostate, and colon. Recently, FOXA1 has been shown to be a major determinant of estrogen-ER activity and endocrine response in breast cancer cells. FOXA1 expression correlates with estrogen receptor (ER)-positivity, especially in luminal subtype A breast cancers, which is associated with favorable prognosis. FOXA1 is useful in the sub-classification of breast carcinomas.
Epitope: The transcription factor Forkhead-box A1 (FOXA1), also known as hepatocyte nuclear factor 3-alpha, is a member of the FOX class of transcription factors. HNF-1 (alpha and beta), HNF-3 (alpha, beta and gamma), HNF-4 (alpha and gamma), and HNF-6 compose, in part, a homeoprotein family designated the hepatocyte nuclear factor family. The various HNF-1 isoforms regulate transcription of genes in the liver as well as in other tissues such as kidney, small intestine and thymus. FOXA1 is expressed in normal breast ductal epithelium and other epithelium in different organs, such as lung, pancreas, bladder, prostate, and colon. Recently, FOXA1 has been shown to be a major determinant of estrogen-ER activity and endocrine response in breast cancer cells. FOXA1 expression correlates with estrogen receptor (ER)-positivity, especially in luminal subtype A breast cancers, which is associated with favorable prognosis. FOXA1 is useful in the sub-classification of breast carcinomas.
Gene Name: FOXA1

Antibody

Host Species: Mouse
Clonality: Recombinant Monoclonal
Clone: rFOXA1/1515
Origin Species: Human

Immunogen

Immunogen: Recombinant human FOXA1 protein fragment (around aa372-472). Antigen Molecular Weight: 49 kDa
Immunogen Type: Recombinant Protein Fragment