LSBio
PathPlus™ CD63 Antibody (clone rMX-49.129.5)

Human Pancreas: Formalin-Fixed, Paraffin-Embedded (FFPE)

PathPlus™ CD63 Antibody (clone rMX-49.129.5)

Primary AntibodyLSBio Guarantee
Antibody:Mouse Recombinant Monoclonal
Applications:Immunohistochemistry (general)
Reactivity:Human
Format:Liquid
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$536.00each
Catalog Number: LS-B16236-100

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Overview

Description
CD63 antibody LS-B16236 is an unconjugated mouse recombinant monoclonal antibody to human CD63. Validated for IHC.
Application
IHC
Reactivity
Hu
Intended Use
Research Use Only
Guarantees
This product carries the LSBio 100% Guarantee. ✓
Category
Antibodies > Primary Antibodies > Recombinant Antibodies
Alternative Names
CD63 molecule | LAMP-3 | ME491 | Granulophysin | MLA1 | Tetraspanin-30 | Tspan-30 | CD63 | CD63 antigen | OMA81H | TSPAN30
Recommended Dilution: IHC-P
1:500
UniProt Number
P08962
NCBI GenBank
NM_001780 | NP_001771.1
SwissProt
P08962

Target

Target
CD63
Antigen Species
Human
Specificity
This MAb recognizes protein of 26 kDa -60 kDa , which is identified as CD63. Its epitope is different from that of MAb LAMP3/529. The tetraspanins are integral membrane proteins expressed on cell surface and granular membranes of hematopoietic cells and are components of multi-molecular complexes with specific integrins. The tetraspanin CD63 is a lysosomal membrane glycoprotein that translocates to the plasma membrane after platelet activation. CD63 is expressed on activated platelets, monocytes and macrophages, and is weakly expressed on granulocytes, T cell and B cells. It is located on the basophilic granule membranes and on the plasma membranes of lymphocytes and granulocytes. CD63 is a member of the TM4 superfamily of leukocyte glycoproteins that includes CD9, CD37 and CD53, which contain four transmembrane regions. CD63 may play a role in phagocytic and intracellular lysosome-phagosome fusion events. CD63 deficiency is associated with Hermansky-Pudlak syndrome and is strongly expressed during the early stages of melanoma progression.
Epitope
This MAb recognizes protein of 26 kDa -60 kDa , which is identified as CD63. Its epitope is different from that of MAb LAMP3/529. The tetraspanins are integral membrane proteins expressed on cell surface and granular membranes of hematopoietic cells and are components of multi-molecular complexes with specific integrins. The tetraspanin CD63 is a lysosomal membrane glycoprotein that translocates to the plasma membrane after platelet activation. CD63 is expressed on activated platelets, monocytes and macrophages, and is weakly expressed on granulocytes, T cell and B cells. It is located on the basophilic granule membranes and on the plasma membranes of lymphocytes and granulocytes. CD63 is a member of the TM4 superfamily of leukocyte glycoproteins that includes CD9, CD37 and CD53, which contain four transmembrane regions. CD63 may play a role in phagocytic and intracellular lysosome-phagosome fusion events. CD63 deficiency is associated with Hermansky-Pudlak syndrome and is strongly expressed during the early stages of melanoma progression.
Gene Name
CD63

Antibody

Host Species
Mouse
Clonality
Recombinant Monoclonal
Clone
rMX-49.129.5
Light Chain
Kappa Light Chain
Origin Species
Human

Immunogen

Immunogen
Smooth plasma membrane fraction of MeWo cells. Antigen Molecular Weight: 26 kDa (core protein) - 30-60 kDa (glycosylated)
Immunogen Type
Cell-Based Immunization

Format

Conjugate/Label
Unconjugated
Format
Liquid
Formulation
10 mM PBS, 0.05% BSA, 0.05% Sodium Azide
Concentration
200 µg/mL
Animal Free
No
Carrier-Free
No
Preservative
Yes
Purification Method
Protein A/G Affinity

Storage & Handling

Storage Conditions
Store at 2°C to 8°C for up to 2 years.
Recommended Storage Buffer
10 mM PBS

Request SDS/MSDS

To request an SDS/MSDS form for this product, please contact our Technical Support department at: technical@vectorlabs.com.