Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)

PathPlus™ AMACR / P504S Antibody (aa 297-394, clone AMACR/2748R)

Primary AntibodyLSBio Guarantee

Antibody:	Rabbit Recombinant Monoclonal
Applications:	Immunohistochemistry (general)
Reactivity:	Human
Format:	Liquid

$536.00each

Catalog Number: LS-B16306-100

Unit Size

Quantity

For bulk orders or custom formulations:

Overview

Description: P504S antibody LS-B16306 is an unconjugated rabbit recombinant monoclonal antibody to human P504S (AMACR) (aa 297-394). Validated for IHC.
Application: IHC
Reactivity: Hu
Intended Use: Research Use Only
Guarantees: This product carries the LSBio 100% Guarantee. ✓
Category: Antibodies > Primary Antibodies > Recombinant Antibodies
Alternative Names: 2-methylacyl-CoA racemase | AMACRD | Alpha-methylacyl-CoA racemase | CBAS4 | RACE | AMACR | RM | AMACR/p504S
Recommended Dilution: IHC-P: 1:100
UniProt Number: Q9UHK6
NCBI GenBank: NM_014324 | NP_055139.4
SwissProt: Q9UHK6

Target

Target: AMACR / P504S
Antigen Species: Human
Specificity: This antibody recognizes a protein of 42 kDa , which is identified as AMACR, also known as p504S. It is an enzyme that is involved in bile acid biosynthesis and beta-oxidation of branched-chain fatty acids. AMACR is essential in lipid metabolism. It is expressed in cells of premalignant high-grade prostatic intraepithelial neoplasia (HGPIN) and prostate adenocarcinoma. The majority of the carcinoma cells show a distinct granular cytoplasmic staining reaction. AMACR is present at low or undetectable levels in glandular epithelial cells of normal prostate and benign prostatic hyperplasia. A spotty granular cytoplasmic staining is seen in a few cells of the benign glands. AMACR is expressed in normal liver (hepatocytes), kidney (tubular epithelial cells) and gall bladder (epithelial cells). Expression has also been found in lung (bronchial epithelial cells) and colon (colonic surface epithelium). AMACR expression can also be found in hepatocellular carcinoma and kidney carcinoma. Past studies have also shown that AMACR is expressed in various colon carcinomas (well, moderately and poorly differentiated) and over expressed in prostate carcinoma.
Epitope: This antibody recognizes human AMACR (p504S), a 42 kDa enzyme that is essential for lipid metabolism.
Gene Name: AMACR

Antibody

Host Species: Rabbit
Clonality: Recombinant Monoclonal
Clone: AMACR/2748R
Origin Species: Human

Immunogen

Immunogen: Recombinant human AMACR protein fragment (around aa 297-394). Antigen Molecular Weight: 42 kDa
Immunogen Type: Recombinant Protein Fragment