Immunofluorescent analysis of PC3 cells using PARG Antibody at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

PARG Antibody

Primary AntibodyLSBio Guarantee

Antibody:	Rabbit Polyclonal
Applications:	Enzyme-Linked Immunosorbent Assay, Immunofluorescence, Immunohistochemistry (general)
Reactivity:	Human
Format:	Liquid

$300.00each

Catalog Number: LS-C501236-50

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Overview

Description: PARG antibody LS-C501236 is an unconjugated rabbit polyclonal antibody to human PARG. Validated for ELISA and IF.
Application: ELISA, IF, IHC
Reactivity: Hu
Intended Use: Research Use Only
Guarantees: This antibody carries the LSBio 100% Guarantee. ✓
Category: Antibodies > Primary Antibodies > Polyclonal Antibodies
Alternative Names: PARG99 | PARG
UniProt Number: Q86W56
NCBI GenBank: NM_003631 | NP_003622.2
SwissProt: Q86W56

Target

Target: Human PARG
Antigen Species: Human
Epitope: Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase (PubMed:23102699). PARG acts both as an endo- and exoglycosidase, releasing PAR of different length as well as ADP-ribose monomers (PubMed:23102699). Required for retinoid acid-dependent gene transactivation, probably by dePARsylating histone demethylase KDM4D, allowing chromatin derepression at RAR-dependent gene promoters (PubMed:23102699). Involved in the synthesis of ATP in the nucleus, together with PARP1, NMNAT1 and NUDT5 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257).
Gene Name: BPHL|PARG