PAPPA / PAPP-A Antibody (clone 10E1)
Primary AntibodyLSBio Guarantee
| Antibody: | Mouse Monoclonal |
| Applications: | Enzyme-Linked Immunosorbent Assay, Immunohistochemistry (general), Immunoprecipitation, Western Blot |
| Reactivity: | Human |
| Format: | Liquid |
$415.00each
Catalog Number: LS-C188475-0.2
Catalog Number: LS-C188475
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- Description
- PAPP-A antibody LS-C188475 is an unconjugated mouse monoclonal antibody to human PAPP-A (PAPPA). Validated for ELISA, IP and WB.
- Application
- ELISA, IHC, IP, WB
- Reactivity
- Hu
- Intended Use
- Research Use Only
- Guarantees
- This antibody carries the LSBio 100% Guarantee. ✓
- Category
- Antibodies > Primary Antibodies > Monoclonal Antibodies
- Alternative Names
- DIPLA1 | IGF-dependent IGFBP-4 protease | PAPPA1 | PAPA | PAPP-A | Pappalysin-1 | ASBABP2 | IGFBP-4ase | PAPPA
- UniProt Number
- Q13219
- NCBI GenBank
- NM_002581 | NP_002572.2
- SwissProt
- Q13219
Target
- Target
- Human PAPPA / PAPP-A
- Antigen Species
- Human
- Epitope
- Recognizes human pregnancy-associated plasma protein A, or PAPP-A, a metalloprotease specific for insulin-like growth factor binding protein-4 and -5 (IGFBP4 and IGFBP5). PAPP-A was initially identified as a high-molecular mass component in human pregnancy serum. In pregnancy serum PAPP-A exists in a disulfide bound heterotetrameric complex consisting of two 200kD PAPP-A subunits and two 50-90kD subunits of the proform of eosinophil major basic protein (proMBP). The concentration of PAPP-A in serum increases with gestational age, however, in Downs syndrome pregnancies PAPP-A concentration is markedly reduced in the first trimester. As such, PAPP-A is widely used as an early marker for Downs syndrome. PAPP-A has also been shown to exist in a homodimeric, 400kD form in unstable atherosclerotic plaques. Increased circulating concentrations of this dimeric PAPP-A are associated with acute coronary syndromes. The antibody recognizes both the heterotetrameric complex (PAPP-A associated with proMBP) and the homodimeric complex of PAPP-A.
- Gene Name
- PAPPA
Antibody
- Host Species
- Mouse
- Clonality
- Monoclonal
- Clone
- 10E1
- Isotype
- IgG2b
Immunogen
- Immunogen
- Purified human PAPP-A/proMBP complex.
- Immunogen Type
- Native Protein (Purified from Natural Source)
Format
- Conjugate/Label
- Unconjugated
- Format
- Liquid
- Formulation
- PBS, 0.09% Sodium Azide
- Concentration
- 1 mg/mL
- Preservative
- Yes
- Purification Method
- Protein A Affinity
Storage & Handling
- Storage Conditions
- Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
- Recommended Storage Buffer
- PBS