Positive WB detected in:Mouse lung tissue,Mouse skeletal muscle tissue;All lanes: PAK3 antibody at 3ug/ml;Secondary;Goat polyclonal to rabbit IgG at 1/50000 dilution;Predicted band size: 63,61,65 kDa;Observed band size: 63 kDa;

PAK3 Antibody

Primary AntibodyLSBio Guarantee

Antibody:	Rabbit Polyclonal
Applications:	Enzyme-Linked Immunosorbent Assay, Immunofluorescence, Immunohistochemistry (general), Western Blot
Reactivity:	Human, Mouse
Format:	Liquid

$300.00each

Catalog Number: LS-C499493-50

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Overview

Description: PAK3 antibody LS-C499493 is an unconjugated rabbit polyclonal antibody to PAK3 from human. It is reactive with human and mouse. Validated for ELISA, IF, IHC and WB.
Application: ELISA, IF, IHC, WB
Reactivity: Hu, Ms
Intended Use: Research Use Only
Guarantees: This antibody carries the LSBio 100% Guarantee. ✓
Category: Antibodies > Primary Antibodies > Polyclonal Antibodies
Alternative Names: Beta-PAK | BPAK | MRX47 | HPAK3 | Oligophrenin-3 | PAK3beta | MRX30 | OPHN3 | p21-activated kinase 3 | PAK-3 | BetaPak | PAK3
UniProt Number: O75914
NCBI GenBank: NM_002578 | NP_002569.1
SwissProt: O75914

Target

Target: Human PAK3
Antigen Species: Human
Epitope: Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development.
Gene Name: PAK3