P2RX7 / P2X7 Antibody (clone Hano43)
Primary AntibodyLSBio Guarantee
| Antibody: | Rat Monoclonal |
| Applications: | Flow Cytometry, Immunofluorescence, Immunohistochemistry (general) |
| Reactivity: | Mouse |
| Format: | Liquid |
$392.00each
Catalog Number: LS-C188553-0.25
Catalog Number: LS-C188553
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- Description
- P2X7 antibody LS-C188553 is an unconjugated rat monoclonal antibody to mouse P2X7 (P2RX7). Validated for Flow and IF.
- Application
- FC, IF, IHC
- Reactivity
- Ms
- Intended Use
- Research Use Only
- Guarantees
- This antibody carries the LSBio 100% Guarantee. ✓
- Category
- Antibodies > Primary Antibodies > Monoclonal Antibodies
- Alternative Names
- ATP receptor | p2X purinoceptor 7 | p2X receptor 7 | p2X7 purinoceptor | p2Z receptor | Purinergic receptor | p2RX7 | p2X7 | p2X7 receptor
- Recommended Dilution: FC
- 1:25 - 1:200
- UniProt Number
- Q99572
- NCBI GenBank
- NM_002562 | NP_002553.3
- SwissProt
- Q99572
Target
- Target
- Mouse P2RX7 / P2X7
- Antigen Species
- Mouse
- Epitope
- Recognizes the P2X purinoceptor 7, also known as P2X7. The P2X7 ATP receptor has a distinctive long C-terminal tail with multiple potential protein and lipid interaction motifs and is highly polymorphic. It is a cation selective ion channel that opens up on binding of extracellular ATP. Sustained activation by extracellular ATP results in the formation of a reversible pore in the plasma membrane that is permeable to hydrophilic solutes of up to 900 Da. Once a pore is opened massive upset of cytoplasmic ion homeostasis occurs and the pore stays open as long as it is bound by ATP. Should ATP stimulation continue the cell will become irreversibly damaged and die. P2X7 plays a key role in the maturation and release of IL-1 and other IL-1 family members during inflammation. As such, P2X7 blockers might be useful as anti-inflammatory agents.
- Gene Name
- P2RX7
Antibody
- Host Species
- Rat
- Clonality
- Monoclonal
- Clone
- Hano43
- Isotype
- IgG2b
Immunogen
- Immunogen
- A P2X7-expression construct and a final boost with P2X7-transfected HEK cells.
- Immunogen Type
- Cell-Based Immunization
Format
- Conjugate/Label
- Unconjugated
- Format
- Liquid
- Formulation
- PBS, 0.09% Sodium Azide
- Concentration
- 1 mg/mL
- Preservative
- Yes
- Purification Method
- Protein G Affinity
Storage & Handling
- Storage Conditions
- Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
- Recommended Storage Buffer
- PBS