Formalin-fixed, paraffin-embedded human Lung Adenocarcinomastained with TTF-1 Mouse Recombinant Monoclonal Antibody (rNX2.1/690).
NKX2-1 / Thyroid-Specific TF Antibody (clone rNX2.1/690, Azide-free, Carrier-free)
Primary AntibodyLSBio Guarantee
| Antibody: | Mouse Recombinant Monoclonal |
| Applications: | Immunohistochemistry, Paraffin |
| Reactivity: | Human |
| Format: | Liquid |
$586.00each
Catalog Number: LS-C751393-100
Catalog Number: LS-C751393
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- Description
- Thyroid-Specific TF antibody LS-C751393 is an unconjugated mouse recombinant monoclonal antibody to human Thyroid-Specific TF (NKX2-1). Validated for IHC.
- Application
- IHC-P
- Reactivity
- Hu
- Intended Use
- Research Use Only
- Guarantees
- This antibody carries the LSBio 100% Guarantee. ✓
- Category
- Antibodies > Primary Antibodies > Recombinant Antibodies
- Alternative Names
- BCH | Benign chorea | Homeobox protein Nkx-2.1 | NK-2 | NKX2.1 | NK-2 homolog A | Thyroid transcription factor 1 | NK2 homeobox 1 | TTF-1 | BHC | Thyroid nuclear factor 1 | TITF1 | NKX2-1 | NKX2A | TEBP
- Recommended Dilution: IHC-P
- 0.5 - 1 µg/ml
- UniProt Number
- P43699
- NCBI GenBank
- NM_003317 | NP_003308.1
- SwissProt
- P43699
Target
- Target
- Human NKX2-1 / Thyroid-Specific TF
- Antigen Species
- Human
- Epitope
- Recognizes a protein of 40 kDa , identified as Thyroid transcription factor-1 (TTF-1). TTF-1 is a member of the NKx2 family of homeodomain transcription factors. It is expressed in epithelial cells of the thyroid gland and the lung. Nuclei from liver, stomach, pancreas, small intestine, colon, kidney, breast, skin, testes, pituitary, prostate, and adrenal glands are unreactive. Anti-TTF-1 is useful in differentiating primary adenocarcinoma of the lung from metastatic carcinomas originating in the breast, mediastinal germ cell tumors, and malignant mesothelioma. It can also be used to differentiate small cell lung carcinoma from lymphoid infiltrates. Loss of TTF-1 expression in non-small cell lung carcinoma has been associated with aggressive behavior of such neoplasms. TTF-1 reactivity is also seen in thyroid malignancies.
- Gene Name
- NKX2-1
Antibody
- Host Species
- Mouse
- Clonality
- Recombinant Monoclonal
- Clone
- rNX2.1/690
- Isotype
- IgG1
- Origin Species
- Human
Immunogen
- Immunogen
- Recombinant full-length human TTF-1 protein. Antigen Molecular Weight: 40 kDa
- Immunogen Type
- Recombinant Immunogen
Format
- Conjugate/Label
- Unconjugated
- Format
- Liquid
- Formulation
- 10 mM PBS
- Concentration
- 1 mg/mL
- Preservative
- No
- Purification Method
- Protein A/G Affinity
Storage & Handling
- Storage Conditions
- Store at -20°C to -80°C for up to 2 years.
- Recommended Storage Buffer
- 10 mM PBS