Formalin-fixed, paraffin-embedded human Breast Carcinoma stained with Major Vault Protein Rabbit Recombinant Monoclonal Antibody (VP2897R).
MVP / VAULT1 Antibody (clone VP2897R)
Primary AntibodyLSBio Guarantee
| Antibody: | Rabbit Recombinant Monoclonal |
| Applications: | Immunohistochemistry, Paraffin |
| Reactivity: | Human |
| Format: | Liquid |
$379.00each
Catalog Number: LS-C751491-20
Catalog Number: LS-C751491
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- Description
- VAULT1 antibody LS-C751491 is an unconjugated rabbit recombinant monoclonal antibody to human VAULT1 (MVP). Validated for IHC.
- Application
- IHC-P
- Reactivity
- Hu
- Intended Use
- Research Use Only
- Guarantees
- This antibody carries the LSBio 100% Guarantee. ✓
- Category
- Antibodies > Primary Antibodies > Recombinant Antibodies
- Alternative Names
- Major vault protein | MVP | VAULT1 | LRP
- Recommended Dilution: IHC-P
- 1 - 2 µg/ml
- UniProt Number
- Q14764
- NCBI GenBank
- NM_017458 | NP_059447.2
- SwissProt
- Q14764
Target
- Target
- Human MVP / VAULT1
- Antigen Species
- Human
- Epitope
- Recognizes a protein of 104 kDa -110 kDa , characterized as major vault protein (MVP). Vaults are large ribonucleoprotein particles (RNPs) present in all eukaryotic cells. They have a complex morphology, including several small molecules of RNA, but a single protein species. The MVP accounts for >70% of their mass. Their shape is reminiscent of the nucleopore central plug. Treatment of cells with estradiol increases the amount of MVP in nuclear extract. The hormone-dependent interaction of vaults with ER is prevented in vitro by sodium molybdate. Antibodies to estrogen, progesterone and glucocorticoid receptors are able to co-immunoprecipitate the MVP. MVP is overexpressed in many neoplastic tissues and cell lines. Expression of MVP predicts a poor response to chemotherapy.
- Gene Name
- MVP
Antibody
- Host Species
- Rabbit
- Clonality
- Recombinant Monoclonal
- Clone
- VP2897R
- Isotype
- IgG
- Origin Species
- Human
Immunogen
- Immunogen
- Recombinant full-length human MVP protein. Antigen Molecular Weight: 104-110 kDa
- Immunogen Type
- Recombinant Immunogen
Format
- Conjugate/Label
- Unconjugated
- Format
- Liquid
- Formulation
- 10 mM PBS, 0.05% BSA, 0.05% Sodium Azide
- Concentration
- 200 µg/mL
- Preservative
- Yes
- Purification Method
- Protein A/G Affinity
Storage & Handling
- Storage Conditions
- Store at 2°C to 8°C for up to 2 years.
- Recommended Storage Buffer
- 10 mM PBS