LSBio
Monoclonal Mouse anti-Human SOS1 Antibody (clone SOS-01, IF, WB)

Monoclonal Mouse anti-Human SOS1 Antibody (clone SOS-01, IF, WB)

Primary AntibodyLSBio Guarantee
Antibody:Mouse Monoclonal
Applications:Enzyme-Linked Immunosorbent Assay, Immunofluorescence, Immunohistochemistry (general), Western Blot
Reactivity:Human
Format:Liquid
See all Human SOS1 antibodies →
$296.00each
Catalog Number: LS-C188432-0.1

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Overview

Description
SOS1 antibody LS-C188432 is an unconjugated mouse monoclonal antibody to human SOS1. Validated for ELISA, IF and WB.
Application
ELISA, IF, IHC, WB
Reactivity
Hu
Intended Use
Research Use Only
Guarantees
This antibody carries the LSBio 100% Guarantee. ✓
Category
Antibodies > Primary Antibodies > Monoclonal Antibodies
Alternative Names
GINGF | NS4 | SOS-1 | Son of sevenless homolog 1 | SOS1 | GF1 | GGF1
UniProt Number
Q07889
NCBI GenBank
NM_005633 | NP_005624.2
SwissProt
Q07889

Target

Target
Human SOS1
Antigen Species
Human
Epitope
Recognizes SOS1 (son of sevenless homolog 1), a ubiquitously expressed 150kD intracellular protein and bifunctional guanine nucleotide exchange factor (GEF), which plays a role in growth and differentiation signalling pathways and in actin reorganization, by acting as a regulator of Ras and Rac/Rho GTPases. Mutations in the SOS1 gene are responsible for the rare oral overgrowth condition known as gingival fibromatosis 1 (GINGF1), and also the cause of the relatively common autosomal dominant disorder Noonan syndrome type 4 (NS4), characterized by short stature, congenital heart malformation, bleeding diathesis and distinctive facial features.
Gene Name
SOS1

Antibody

Host Species
Mouse
Clonality
Monoclonal
Clone
SOS-01
Isotype
IgG1

Immunogen

Immunogen
Synthetic peptide corresponding to amino acids THPSMHRDGPPLLENAHSS of human SOS1. Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla, Orangutan, Gibbon, Monkey, Galago, Marmoset, Mouse, Rat, Ferret, Elephant, Panda, Bovine, Cat, Horse, Rabbit, Opossum, Guinea pig (100%); Dog, Turkey, Zebra finch (95%); Lizard (89%).
Immunogen Type
Synthetic Peptide (Linear)

Format

Conjugate/Label
Unconjugated
Format
Liquid
Formulation
PBS, 0.09% Sodium Azide
Concentration
1 mg/mL
Preservative
Yes
Purification Method
Protein A Affinity

Storage & Handling

Storage Conditions
Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
Recommended Storage Buffer
PBS

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To request an SDS/MSDS form for this product, please contact our Technical Support department at: technical@vectorlabs.com.