LSBio
Monoclonal Mouse anti-Human ER Alpha / Estrogen Receptor Antibody (clone 6F11, Supernatant, IHC)

Monoclonal Mouse anti-Human ER Alpha / Estrogen Receptor Antibody (clone 6F11, Supernatant, IHC)

Primary AntibodyLSBio Guarantee
Antibody:Mouse Monoclonal
Applications:Immunohistochemistry, Frozen, Immunohistochemistry, Paraffin
Reactivity:Human
Format:Lyophilized
See all Human ER Alpha / Estrogen Receptor antibodies →
$1715.00each
Catalog Number: LS-C11577-1

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Overview

Description
Estrogen Receptor antibody LS-C11577 is an unconjugated mouse monoclonal antibody to human Estrogen Receptor (ER Alpha). Validated for IHC.
Application
IHC-F, IHC-P
Reactivity
Hu
Intended Use
Research Use Only
Guarantees
This antibody carries the LSBio 100% Guarantee. ✓
Category
Antibodies > Primary Antibodies > Monoclonal Antibodies
Alternative Names
Era | ERalpha | Estrogen receptor | ER-alpha | Estrogen receptor 1 | NR3A1 | ER | ESR | ESR1 | ESRA | Estrogen receptor alpha
Recommended Dilution: IHC-F
1:40 - 1:60
Recommended Dilution: IHC-P
1:40 - 1:80
UniProt Number
P03372
NCBI GenBank
NM_000125 | NP_000116.2
SwissProt
P03372

Target

Target
Human ER Alpha / Estrogen Receptor
Antigen Species
Human
Epitope
Recognizes the human estrogen receptor alpha chain (ERalpha), also known as the estradiol receptor or nuclear receptor subfamily 3 group A member 1. ERalpha is a ~65kD steroid hormone receptor containing an N-terminal. ligand independent transactivation domain, a DNA binding domain and a C-terminal ligand binding domain which overlaps with an. ERalpha binds to DNA as a homodimer and can also form heterodimers with Estrogen receptor beta The detection of estrogen (ER) and progesterone (PR) receptors using immunohistochemical staining of formalin fixed, paraffin embedded (FFPE) tissue, has gradually replaced ligand binding assays, to become the most common method for the determination of the ER/PR status of breast tumors. Approximately 75% to 80% of breast tumors have estrogen and/or progesterone receptors, and the presence of these receptors helps determine both the patients prognosis and the effectiveness of hormonal therapy. Has been used successfully for identification of ERalpha on breast cancer cell lysates using Western blotting and for the immunohistochemical detection of ERalpha in breast cancer tissues.
Gene Name
ESR1

Antibody

Host Species
Mouse
Clonality
Monoclonal
Clone
6F11
Isotype
IgG1

Immunogen

Immunogen
Recombinant human estrogen receptor (alpha form).
Immunogen Type
Recombinant Immunogen

Format

Conjugate/Label
Unconjugated
Format
Lyophilized
Formulation
0.09% Sodium Azide
Volume
1 Milliliter
Preservative
Yes
Purification Method
Unpurified (Serum / Ascites / Supernatant)

Storage & Handling

Storage Conditions
Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.

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