Monoclonal Rat anti-Mouse CD90.2 (Mouse) Antibody (clone 30H12, AF647)
Catalog Number: LS-C810655
2 sizes / from $259.00
Antibody: Rat Monoclonal
Applications: Flow Cytometry
Reactivity: Mouse
Format: Liquid
Monoclonal Mouse anti-Human EDN1 / Endothelin 1 Antibody (clone IC4, C-Terminus, IHC)
Primary AntibodyLSBio Guarantee
| Antibody: | Mouse Monoclonal |
| Applications: | Immunohistochemistry (general), Immunohistochemistry, Frozen, Other |
| Reactivity: | Human |
| Format: | Liquid |
$286.00each
Catalog Number: LS-C11319-0.1
Catalog Number: LS-C11319
For bulk orders or custom formulations:
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- Description
- Endothelin 1 antibody LS-C11319 is an unconjugated mouse monoclonal antibody to human Endothelin 1 (EDN1) (C-Terminus). Validated for IHC and IRMA. Cited in 1 publication.
- Application
- IHC, IHC-F, Other
- Reactivity
- Hu
- Intended Use
- Research Use Only
- Guarantees
- This antibody carries the LSBio 100% Guarantee. ✓
- Category
- Antibodies > Primary Antibodies > Monoclonal Antibodies
- Alternative Names
- EDN1 | Endothelin 1 | Endothelin-1 | ET1 | Preproendothelin-1 | PPET1 | HDLCQ7
- UniProt Number
- P05305
- NCBI GenBank
- NM_001955 | NP_001946.3
- SwissProt
- P05305
Target
- Target
- Human EDN1 / Endothelin 1
- Antigen Species
- Human
- Epitope
- Recognizes human endothelin 1 (ET-1). Endothelin-1 in it's precursor form is a 212 amino acid protein with a 17 aa signal peptide, an N-terminal pro-peptide region and a C-terminal pro-peptide region flanking the endothelin peptides, big endothelin-1 (38aa), the precursor of the smaller endothelin peptide which is cleaved by endothelin converting enzyme to produce the active endothelin-1 (21aa) peptide and a c-terminal fragment. Endothelin-1 is a potent vasoconstrictor with a molecular weight of approximately 25 kD. Shows less than 10% reactivity with endothelin 3. Plasma levels of both endothelin-1 and big endothelin-1 are useful as predictors for survival of patients with congestive heart failure. However, the half life of the endothlin1 peptide in human plasma is very short (c1.0mins) and measurement of big-endothelin-1 may be a more reliable measure of the endothelin secretory pathway activity.
- Gene Name
- EDN1
Antibody
- Host Species
- Mouse
- Clonality
- Monoclonal
- Clone
- IC4
- Isotype
- IgG1
Immunogen
- Immunogen
- C-Terminus fragment of human endothelin 1.
Format
- Conjugate/Label
- Unconjugated
- Format
- Liquid
- Formulation
- PBS, 0.1% Sodium Azide
- Concentration
- 1 mg/mL
- Preservative
- Yes
- Purification Method
- Protein A Affinity
Storage & Handling
- Storage Conditions
- Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
- Recommended Storage Buffer
- PBS
Estrogen and progesterone regulate expression of the endothelins in the rhesus macaque endometrium. Keator CS, Mah K, Ohm L, Slayden OD. Human reproduction (Oxford, England). 2011;26:1715-28. PubMed: 21505040 PMC: PMC3113504
