Monoclonal Rat anti-Mouse CD90.2 (Mouse) Antibody (clone 30H12, AF647)
Catalog Number: LS-C810655
2 sizes / from $259.00
Antibody: Rat Monoclonal
Applications: Flow Cytometry
Reactivity: Mouse
Format: Liquid
Monoclonal Mouse anti-Human CLU / Clusterin Antibody (clone 3R3/2, IHC, WB)
Primary AntibodyLSBio Guarantee
| Antibody: | Mouse Monoclonal |
| Applications: | Enzyme-Linked Immunosorbent Assay, Flow Cytometry, Immunohistochemistry (general), Immunohistochemistry, Frozen, Western Blot |
| Reactivity: | Human |
| Format: | Liquid |
$573.00each
Catalog Number: LS-C44980-0.1
Catalog Number: LS-C44980
For bulk orders or custom formulations:
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- Description
- Clusterin antibody LS-C44980 is an unconjugated mouse monoclonal antibody to human Clusterin (CLU). Validated for ELISA, Flow, IHC and WB. Cited in 1 publication.
- Application
- ELISA, FC, IHC, IHC-F, WB
- Reactivity
- Hu
- Intended Use
- Research Use Only
- Guarantees
- This antibody carries the LSBio 100% Guarantee. ✓
- Category
- Antibodies > Primary Antibodies > Monoclonal Antibodies
- Alternative Names
- APO-J | Apolipoprotein J | CLU1 | Clusterin | Complement lysis inhibitor | CLI | AAG4 | Aging-associated protein 4 | Ku70-binding protein 1 | KUB1 | SGP2 | APOJ | SGP-2 | Sulfated glycoprotein 2 | CLU | CLU2 | Complement cytolysis inhibitor | NA1/NA2 | SP-40
- UniProt Number
- P10909
- NCBI GenBank
- NM_001831 | NP_001822.3
- SwissProt
- P10909
Target
- Target
- Human CLU / Clusterin
- Antigen Species
- Human
- Epitope
- Recognizes clusterin, an ubiquitously expressed protein of two 40-kD chains, alpha and beta, covalently joined by disulfide bonds. It exists in two forms; a pro-apoptotic form localized to the nucleus and a pro-survival secreted form. Both are thought to be involved in DNA repair and cell cycle regulation. The secreted form is thought to inhibit apoptotic signalling by BAX, Clusterin suppression can sensitize cells to chemotherapy. Clusterin is overexpressed in human prostate cancer, breast cancers and squamous cell carcinomas. Part of the SC5b-9 complex, clusterin prevents the binding of a C5b-C7 complex to the membrane of the target cell inhibiting the complement cascade. Clusterin acts as an extracellular chaperone inhibiting the formation of human lysozyme amyloid associated with Alzheimer's disease. Clusterin is also important in spermatogenesis and is secreted by Sertoli cells.
- Gene Name
- CLU
Antibody
- Host Species
- Mouse
- Clonality
- Monoclonal
- Clone
- 3R3/2
- Isotype
- IgG1
Immunogen
- Immunogen
- Glomerular basement membrane from a post-mortem kidney.
- Immunogen Type
- Tissue Extract
Format
- Conjugate/Label
- Unconjugated
- Format
- Liquid
- Formulation
- BBS, 0.1% Sodium Azide
- Concentration
- 1 mg/mL
- Preservative
- Yes
- Purification Method
- Protein A Affinity
Storage & Handling
- Storage Conditions
- Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
- Recommended Storage Buffer
- bbs
Cerebrospinal Fluid Particles in Alzheimer Disease and Parkinson Disease. Yang Y, Keene CD, Peskind ER, Galasko DR, Hu SC, Cudaback E, Wilson AM, Li G, Yu CE, Montine KS, Zhang J, Baird GS, Hyman BT, Montine TJ. Journal of neuropathology and experimental neurology. 2015;74:672-87. PubMed: 26083568 PMC: PMC4471879
