Bovine lipoprotein lipase detected with Mouse anti-lipoprotein lipase followed by Rabbit F(ab')2 anti-Mouse IgG:HRP
LPL / Lipoprotein Lipase Antibody (clone 5D2)
Primary AntibodyLSBio Guarantee
| Antibody: | Mouse Monoclonal |
| Applications: | Enzyme-Linked Immunosorbent Assay, Immunohistochemistry (general), Immunoprecipitation, Western Blot |
| Reactivity: | Bovine |
| Format: | Liquid |
$415.00each
Catalog Number: LS-C188626-0.2
Catalog Number: LS-C188626
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- Description
- Lipoprotein Lipase antibody LS-C188626 is an unconjugated mouse monoclonal antibody to bovine Lipoprotein Lipase (LPL). Validated for ELISA, IP and WB.
- Application
- ELISA, IHC, IP, WB
- Reactivity
- Bov
- Nonreactive Species
- Mouse
- Intended Use
- Research Use Only
- Guarantees
- This antibody carries the LSBio 100% Guarantee. ✓
- Category
- Antibodies > Primary Antibodies > Monoclonal Antibodies
- Alternative Names
- LIPD | Lipoprotein lipase | LPL | HDLCQ11
- UniProt Number
- P06858
- NCBI GenBank
- NM_000237 | NP_000228.1
- SwissProt
- P06858
Target
- Target
- Bovine LPL / Lipoprotein Lipase
- Antigen Species
- Bovine
- Epitope
- Recognizes an epitope within amino acids 380-410 of lipoprotein lipase (LPL), a member of the AB hydrolase superfamily, which plays a pivotal role in lipoprotein metabolism and transport, acting as the key enzyme in the hydrolysis of triglycerides and very low density lipoproteins (VLDLs), and the release of free fatty acids into peripheral tissues. A deficiency of LPL can result in hypertriglyceridemia, and many studies have focused on the critical role which LPL plays in the pathogenesis of atherosclerosis, and in particular the relationship between LPL and apolipoprotein E (ApoE), both of which are secreted in significant amounts by macrophages in developing arterial wall lesions. Clone 5D2 is a unique antibody which differentiates between monomeric inactive and dimeric active LPL, and binds to LPL sequences involved in LPL, LPL receptor, and heparin interactions. Clone 5D2 has been shown to inhibit the activity of human LPL(2,3), and is widely used in human studies.
- Gene Name
- LPL
Antibody
- Host Species
- Mouse
- Clonality
- Monoclonal
- Clone
- 5D2
- Isotype
- IgG1
Immunogen
- Immunogen
- Purified bovine milk lipoprotein lipase.
- Immunogen Type
- Native Protein (Purified from Natural Source)
Format
- Conjugate/Label
- Unconjugated
- Format
- Liquid
- Formulation
- PBS, 0.09% Sodium Azide
- Concentration
- 1 mg/mL
- Preservative
- Yes
- Purification Method
- Protein G Affinity
Storage & Handling
- Storage Conditions
- Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
- Recommended Storage Buffer
- PBS