Immunohistochemistry of paraffin-embedded human lymph node tissue using KPNA2 Antibody at dilution of 1:100
KPNA2 / Importin Alpha 1 Antibody
Primary AntibodyLSBio Guarantee
| Antibody: | Rabbit Polyclonal |
| Applications: | Enzyme-Linked Immunosorbent Assay, Immunofluorescence, Immunohistochemistry (general), Western Blot |
| Reactivity: | Human, Mouse |
| Format: | Liquid |
$300.00each
Catalog Number: LS-C499202-50
Catalog Number: LS-C499202
For bulk orders or custom formulations:
Request a QuoteOverview
- Description
- Importin Alpha 1 antibody LS-C499202 is an unconjugated rabbit polyclonal antibody to Importin Alpha 1 (KPNA2) from human. It is reactive with human and mouse. Validated for ELISA, IF, IHC and WB.
- Application
- ELISA, IF, IHC, WB
- Reactivity
- Hu, Ms
- Intended Use
- Research Use Only
- Guarantees
- This antibody carries the LSBio 100% Guarantee. ✓
- Category
- Antibodies > Primary Antibodies > Polyclonal Antibodies
- Alternative Names
- Importin alpha 2 | Importin subunit alpha-2 | IPOA1 | Importin alpha-2 subunit | Karyopherin subunit alpha-2 | KPNA2 | Importin-alpha-P1 | Qip2 | RAG cohort 1 | SRP1 | RCH1 | SRP1-alpha | SRP1alpha | Importin alpha 1 | Pendulin | RAG cohort protein 1
- UniProt Number
- P52292
- NCBI GenBank
- NM_002266 | NP_002257.1
- SwissProt
- P52292
Target
- Target
- Human KPNA2 / Importin Alpha 1
- Antigen Species
- Human
- Epitope
- Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
- Gene Name
- KPNA2
Antibody
- Host Species
- Rabbit
- Clonality
- Polyclonal
- Isotype
- IgG
Immunogen
- Immunogen
- Recombinant human Importin subunit alpha-1 protein (2-285AA)
- Immunogen Type
- Recombinant Immunogen
Format
- Conjugate/Label
- Unconjugated
- Format
- Liquid
- Formulation
- PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol.
- Preservative
- Yes
- Purification Method
- Protein G Affinity
Storage & Handling
- Storage Conditions
- Short term: -20°C; Long term: -80°C; Avoid freeze-thaw cycles.
- Recommended Storage Buffer
- PBS