Immunohistochemistry of paraffin-embedded human spleen tissue using KLRK1 Antibody at dilution of 1:100
KLRK1 / CD314 / NKG2D Antibody
Primary AntibodyLSBio Guarantee
| Antibody: | Rabbit Polyclonal |
| Applications: | Enzyme-Linked Immunosorbent Assay, Immunofluorescence, Immunohistochemistry (general) |
| Reactivity: | Human |
| Format: | Liquid |
$300.00each
Catalog Number: LS-C499208-50
Catalog Number: LS-C499208
For bulk orders or custom formulations:
Request a QuoteOverview
- Description
- NKG2D antibody LS-C499208 is an unconjugated rabbit polyclonal antibody to human NKG2D (KLRK1 / CD314). Validated for ELISA, IF and IHC.
- Application
- ELISA, IF, IHC
- Reactivity
- Hu
- Intended Use
- Research Use Only
- Guarantees
- This antibody carries the LSBio 100% Guarantee. ✓
- Category
- Antibodies > Primary Antibodies > Polyclonal Antibodies
- Alternative Names
- D12S2489E | CD314 antigen | KLR | KLRK1 | NK cell receptor D | NKG2D | NKG2-D | NKG2-D-activating NK receptor | CD314
- UniProt Number
- P26718
- NCBI GenBank
- NM_007360 | NP_031386.2
- SwissProt
- P26718
Target
- Target
- Human KLRK1 / CD314 / NKG2D
- Antigen Species
- Human
- Epitope
- Function as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. Participates in NK cell-mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins including MICA, MICB, RAET1E, RAET1G, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4.
- Gene Name
- KLRC4-KLRK1|KLRK1
Antibody
- Host Species
- Rabbit
- Clonality
- Polyclonal
- Isotype
- IgG
Immunogen
- Immunogen
- Recombinant Human NKG2-D type II integral membrane protein (73-216AA)
- Immunogen Type
- Recombinant Immunogen
Format
- Conjugate/Label
- Unconjugated
- Format
- Liquid
- Formulation
- PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol.
- Concentration
- 1 mg/mL
- Preservative
- Yes
- Purification Method
- Protein G Affinity
Storage & Handling
- Storage Conditions
- Short term: store at -20°C. Long term: store at -80°C. Avoid freeze-thaw cycles.
- Recommended Storage Buffer
- PBS