NucleoProtein Antibody
Catalog Number: LS-C834788
2 sizes / from $369.00
Antibody: Rabbit Polyclonal
Applications: Enzyme-Linked Immunosorbent Assay
Reactivity: Human, Virus / Viral Antigen
Format: Liquid
Positive WB detected in Recombinant protein;All lanes:N antibody at 3?g/ml;Secondary;Goat polyclonal to rabbit IgG at 1/50000 dilution;predicted band size: 64 KDa;observed band size: 64 KDa;
JUNV Nucleoprotein Antibody
Primary AntibodyLSBio Guarantee
| Antibody: | Rabbit Polyclonal |
| Applications: | Enzyme-Linked Immunosorbent Assay, Western Blot |
| Reactivity: | Virus / Viral Antigen |
| Format: | Liquid |
$300.00each
Catalog Number: LS-C500445-50
Catalog Number: LS-C500445
For bulk orders or custom formulations:
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- Description
- JUNV Nucleoprotein antibody LS-C500445 is an unconjugated rabbit polyclonal antibody to junin mammarenavirus JUNV Nucleoprotein. Validated for ELISA and WB. Cited in 1 publication.
- Application
- ELISA, WB
- Reactivity
- Vir
- Intended Use
- Research Use Only
- Guarantees
- This antibody carries the LSBio 100% Guarantee. ✓
- Category
- Antibodies > Primary Antibodies > Polyclonal Antibodies
Target
- Target
- Junin mammarenavirus JUNV Nucleoprotein
- Antigen Species
- Virus / Viral Antigen
- Epitope
- Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC). Serves as template for viral transcription and replication. The increased presence of protein N in host cell does not seem to trigger the switch from transcription to replication as observed in other negative strain RNA viruses. Disables the host innate defense by interfering with beta interferon (IFNB) production through the inhibition of host IRF3 phosphorylation and activation by host IKBKE. Through the interaction with host IKBKE, strongly inhibits the phosphorylation and nuclear translocation of IRF3, a protein involved in IFN activation pathway, leading to the inhibition of IFNB and IRF3-dependent promoters activation (By similarity). Interacts with host IKBKE (via Protein kinase domain); the interaction inhibits IKBKE kinase activity.
Antibody
- Host Species
- Rabbit
- Clonality
- Polyclonal
- Isotype
- IgG
Immunogen
- Immunogen
- Recombinant Junin mammarenavirus Nucleoprotein protein (1-564AA)
- Immunogen Type
- Recombinant Immunogen
Format
- Conjugate/Label
- Unconjugated
- Format
- Liquid
- Formulation
- PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol.
- Preservative
- Yes
- Purification Method
- Protein G Affinity
Storage & Handling
- Storage Conditions
- Short term: -20°C; Long term: -80°C; Avoid freeze-thaw cycles.
- Recommended Storage Buffer
- PBS
Therapy for Argentine hemorrhagic fever in nonhuman primates with a humanized monoclonal antibody. Larry Zeitlin, Robert W Cross , Joan B Geisbert , Viktoriya Borisevich , Krystle N Agans , Abhishek N Prasad , Sven Enterlein, M Javad Aman, Zachary A Bornholdt, Miles B Brennan, Lioudmila Campbell, Do Kim, Neil Mlakar, Crystal L Moyer, Michael H Pauly, William Shestowsky, Kevin J Whaley, Karla A Fenton , Thomas W Geisbert. Proceedings of the National Academy of Sciences of the United States of America. 2021 Mar;118:e2023332118. PubMed: 33836604 PMC: PMC7980402
