Formalin-fixed, paraffin-embedded human Placenta stained with Insulin Receptor Rabbit Recombinant Monoclonal Antibody (INSR/2277R).
INSR / Insulin Receptor Antibody (clone INSR/2277R)
Primary AntibodyLSBio Guarantee
| Antibody: | Rabbit Recombinant Monoclonal |
| Applications: | Immunohistochemistry, Paraffin |
| Reactivity: | Human |
| Format: | Liquid |
$379.00each
Catalog Number: LS-C751218-20
Catalog Number: LS-C751218
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- Description
- Insulin Receptor antibody LS-C751218 is an unconjugated rabbit recombinant monoclonal antibody to human Insulin Receptor (INSR). Validated for IHC.
- Application
- IHC-P
- Reactivity
- Hu
- Intended Use
- Research Use Only
- Guarantees
- This antibody carries the LSBio 100% Guarantee. ✓
- Category
- Antibodies > Primary Antibodies > Recombinant Antibodies
- Alternative Names
- CD220 | ILP receptor | Insulin receptor | IR | HHF5 | INSR | CD220 antigen
- Recommended Dilution: IHC-P
- 1 - 2 µg/ml
- UniProt Number
- P06213
- NCBI GenBank
- NM_000208 | NP_000199.2
- SwissProt
- P06213
Target
- Target
- Human INSR / Insulin Receptor
- Antigen Species
- Human
- Epitope
- The insulin receptor (INSR) is a heterodimeric protein complex that has an intracellular beta subunit and an extracellular alpha subunit, which is disulfide-linked to a transmembrane segment. The insulin ligand binds to the INSR and initiates molecular signaling pathways that promote glucose uptake in cells and glycogen synthesis. Insulin binding to INSR induces phosphorylation of intra-cellular tyrosine kinase domains and recruitment of multiple SH2 and SH3 domain-containing intracellular proteins that serve as signaling intermediates for pleiotropic effects of insulin. Type 1 diabetes is an autoimmune condition of the endocrine pancreas that results in destruction of insulin secreting cells and a progressive loss in insulin-sensitive glucose uptake by cells.
- Gene Name
- INSR
Antibody
- Host Species
- Rabbit
- Clonality
- Recombinant Monoclonal
- Clone
- INSR/2277R
- Isotype
- IgG
- Origin Species
- Human
Immunogen
- Immunogen
- Recombinant fragment of extracellular domain of human Insulin Receptor alpha. Antigen Molecular Weight: 135 kDa
- Immunogen Type
- Recombinant Protein Fragment
Format
- Conjugate/Label
- Unconjugated
- Format
- Liquid
- Formulation
- 10 mM PBS, 0.05% BSA, 0.05% Sodium Azide
- Concentration
- 200 µg/mL
- Preservative
- Yes
- Purification Method
- Protein A/G Affinity
Storage & Handling
- Storage Conditions
- Store at 2°C to 8°C for up to 2 years.
- Recommended Storage Buffer
- 10 mM PBS