Immunohistochemistry of paraffin-embeddedi human spleen stained with Goat anti-human IL-23 Receptor

IL23R Antibody (aa59-87)

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Antibody:	Goat Polyclonal
Applications:	Immunohistochemistry (general), Immunohistochemistry, Paraffin, Western Blot
Reactivity:	Human
Format:	Liquid

$436.00each

Catalog Number: LS-C187852-0.1

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Description: IL23R antibody LS-C187852 is an unconjugated goat polyclonal antibody to human IL23R (aa59-87). Validated for IHC and WB.
Application: IHC, IHC-P, WB
Reactivity: Hu
Intended Use: Research Use Only
Guarantees: This antibody carries the LSBio 100% Guarantee. ✓
Category: Antibodies > Primary Antibodies > Polyclonal Antibodies
Alternative Names: IL-23 receptor | Interleukin 23 receptor | IBD17 | IL23R | IL-23R | Interleukin-23 receptor
Recommended Dilution: IHC-P: 1:125
Recommended Dilution: WB: 1:500
UniProt Number: Q5VWK5
NCBI GenBank: NM_144701 | NP_653302.2
SwissProt: Q5VWK5

Target: Human IL23R
Antigen Species: Human
Epitope: Recognizes the human interleukin-23 receptor (IL-23R). The interleukin-23 receptor is 629 amino acid ~72kD single pass type I transmembrane glycoprotein belonging to the type I cytokine receptor family and possessing two domains. Multiple potential isoforms formed by alternative splicing are described. Recognizes an epitope within the N-terminal (NT) region of Interleukin-23 receptor (IL-23R), present in isoforms 1, 3 and 4, the antibody is not expected to recognize other truncated forms of the receptor lacking the immunogen sequence. IL-23R is a mediator of T-cell, NK cell, and possibly macrophage/myeloid cell, stimulation acting as the receptor for IL-23, by association with the beta component of IL-12R and is thought to signal through activation of the JAK-STAT signalling pathway. Genetic variation in IL23R is associated with inflammatory bowel disease type 17 and susceptibility to the ulcerative and inflammatory psoriasis. Is reported as suitable for use in immunocytochemistry on acetone fixed cells and has been used successfully for the immunohistochemical localization of IL-23R in formalin fixed, paraffin embedded human tissues.
Gene Name: IL23R

Immunogen: Synthetic peptide CQPRKLHFYKNGIKERFQITRINKTTARL corresponding to amino acids 59-87 within the N-Terminus of human IL-23 receptor. Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla, Orangutan (100%); Marmoset, Dog (97%); Gibbon, Monkey, Panda (93%); Ferret, Bovine, Cat, Horse, Pig (90%).
Immunogen Type: Synthetic Peptide (Linear)

Storage Conditions: Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
Recommended Storage Buffer: PBS