Immunohistochemistry of paraffin-embedded human lung tissue using TYRO3 Antibody at dilution of 1:100

IHC-plus™ TYRO3 Antibody

Antibody:	Rabbit Polyclonal
Applications:	Enzyme-Linked Immunosorbent Assay, Immunofluorescence, Immunohistochemistry (general), Immunohistochemistry, Paraffin
Reactivity:	Human
Format:	Liquid

$383.00each

Catalog Number: LS-B15188-50

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Overview

Description: TYRO3 antibody LS-B15188 is an unconjugated rabbit polyclonal antibody to human TYRO3. Validated for ELISA, IF and IHC. Tested on 20 paraffin-embedded human tissues.
Application: ELISA, IF, IHC, IHC-P
Reactivity: Hu
Intended Use: Research Use Only
Guarantees: This product carries the LSBio 100% Guarantee. ✓
Category: Antibodies > Primary Antibodies > Polyclonal Antibodies
Alternative Names: Brt | BYK | Dtk | Sky kinase | Sky | Tif | Tyrosine-protein kinase byk | Tyrosine-protein kinase SKY | Tyrosine-protein kinase DTK | TYRO3 | TYRO3 protein tyrosine kinase | Tyrosine-protein kinase brt | RSE | Tyrosine-protein kinase RSE
Recommended Dilution: IHC-P: 10 µg/ml
UniProt Number: Q06418
NCBI GenBank: NM_006293 | NP_006284.2
SwissProt: Q06418

Target

Target: TYRO3
Antigen Species: Human
Specificity: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.
Epitope: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.
Gene Name: TYRO3