Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)

IHC-plus™ SYK Antibody (aa5-360, clone SYK-01)

Primary AntibodyLSBio Guarantee

Antibody:	Mouse Monoclonal
Applications:	Immunohistochemistry (general), Immunohistochemistry, Paraffin, Immunoprecipitation, Western Blot
Reactivity:	Human
Format:	Liquid

$383.00each

Catalog Number: LS-B11825-0.05

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Overview

Description: SYK antibody LS-B11825 is an unconjugated mouse monoclonal antibody to human SYK (aa5-360). Validated for IHC, IP and WB. Tested on 20 paraffin-embedded human tissues.
Application: IHC, IHC-P, IP, WB
Reactivity: Hu
Intended Use: Research Use Only
Guarantees: This product carries the LSBio 100% Guarantee. ✓
Category: Antibodies > Primary Antibodies > Monoclonal Antibodies
Alternative Names: p72syk | Spleen tyrosine kinase | Syk protein-tyrosine kinase | Tyrosine-protein kinase SYK | p72-Syk | SYK
Recommended Dilution: IHC-P: 10 µg/ml
UniProt Number: P43405
NCBI GenBank: NM_003177 | NP_003168.2
SwissProt: P43405

Target

Target: SYK
Antigen Species: Human
Specificity: Recognizes protein tyrosine kinase p72syk (syk), a 72kD non-receptor tyrosine kinase, critical for immunoreceptor signaling in hematopoietic cells, but also expressed by nonhematopoietic cells, including fibroblasts, endothelial cells and hepatocytes. Syk plays an important role in mast cell response, initiated by the aggregation of the IgE high affinity receptor Fc epsilon R1. Phosphorylation of ITAMs within Fc receptor R1 by another tyrosine kinase lyn, results in the recruitment of syk, which is then responsible for the further phosphorylation of numerous target proteins within many different signal transduction pathways. Further studies have shown that syk also plays a major role in B cell receptor-mediated apoptosis, proliferation and hematopoiesis. Syk is also reported to associate with protein kinase C alpha during platelet activation.
Epitope: Recognizes protein tyrosine kinase p72syk (syk), a 72kD non-receptor tyrosine kinase, critical for immunoreceptor signaling in hematopoietic cells, but also expressed by nonhematopoietic cells, including fibroblasts, endothelial cells and hepatocytes. Syk plays an important role in mast cell response, initiated by the aggregation of the IgE high affinity receptor Fc epsilon R1. Phosphorylation of ITAMs within Fc receptor R1 by another tyrosine kinase lyn, results in the recruitment of syk, which is then responsible for the further phosphorylation of numerous target proteins within many different signal transduction pathways. Further studies have shown that syk also plays a major role in B cell receptor-mediated apoptosis, proliferation and hematopoiesis. Syk is also reported to associate with protein kinase C alpha during platelet activation.
Gene Name: SYK