PTGS2 / COX2 / COX-2 Antibody
Catalog Number: LS-C22379-100
100 µg / $740.00
Antibody: Mouse Monoclonal
Applications: Enzyme-Linked Immunosorbent Assay, Western Blot
Reactivity: Human
Format: Liquid
Anti-COX-2 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:500.
IHC-plus™ PTGS2 / COX2 / COX-2 Antibody
Primary AntibodyLSBio Guarantee
| Antibody: | Rabbit Polyclonal |
| Applications: | Enzyme-Linked Immunosorbent Assay, Immunohistochemistry (general), Immunohistochemistry, Paraffin, Western Blot |
| Reactivity: | Human, Mouse, Rat |
| Format: | Liquid |
$505.00each
Catalog Number: LS-B410-50
Catalog Number: LS-B410
For bulk orders or custom formulations:
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- Description
- COX-2 antibody LS-B410 is an unconjugated rabbit polyclonal antibody to COX-2 (PTGS2 / COX2) from human. It is reactive with human, mouse and rat. Validated for ELISA, IHC and WB. Tested on 20 paraffin-embedded human tissues. Cited in 2 publications.
- Application
- ELISA, IHC, IHC-P, WB
- Reactivity
- Hu, Ms, Rt
- Intended Use
- Research Use Only
- Guarantees
- This product carries the LSBio 100% Guarantee. ✓
- Category
- Antibodies > Primary Antibodies > Polyclonal Antibodies
- Alternative Names
- COX-2 | Cyclooxygenase-2 | COX2 | Cyclooxygenase 2b | HCox-2 | GRIPGHS | PGH synthase 2 | PGHS-2 | PHS II | PHS-2 | Prostaglandin H2 synthase 2 | PTGS2 | PGG/HS | Prostaglandin G/H synthase 2
- Recommended Dilution: ELISA
- 1:10000 - 1:50000
- Recommended Dilution: IHC-P
- 1:500
- Recommended Dilution: WB
- 1:5000 - 1:10000
- UniProt Number
- P35354
- NCBI GenBank
- NM_000963 | NP_000954.1
- SwissProt
- P35354
Target
- Target
- PTGS2 / COX2 / COX-2
- Antigen Species
- Human
- Specificity
- This antiserum is directed against human Cox-2 and is useful in determining its presence in western blotting and ELISA experiments. The antibody does not cross react with Cox-1. Cox-2 is involved in the response of cells to growth factors, tumor promoters, and cytokines that induce its expression. Given its role in synthesizing prostaglandins, Cox-2 is therefore of interest in studying immune response regulation. This antibody can detect Cox-2 in human, mouse and rat. Reactivity of this antibody with Cox-2 from other species is unknown.
- Epitope
- This antiserum is directed against human Cox-2 and is useful in determining its presence in western blotting and ELISA experiments. The antibody does not cross react with Cox-1. Cox-2 is involved in the response of cells to growth factors, tumor promoters, and cytokines that induce its expression. Given its role in synthesizing prostaglandins, Cox-2 is therefore of interest in studying immune response regulation. This antibody can detect Cox-2 in human, mouse and rat. Reactivity of this antibody with Cox-2 from other species is unknown.
- Gene Name
- PTGS2
Antibody
- Host Species
- Rabbit
- Clonality
- Polyclonal
- Origin Species
- Human
Immunogen
- Immunogen
- This whole rabbit serum was prepared by repeated immunizations with a fusion protein corresponding to the carboxy-terminus of human Cox-2.
- Immunogen Type
- Fusion Protein (e.g., GST, MBP tag)
Format
- Conjugate/Label
- Unconjugated
- Format
- Liquid
- Formulation
- Antiserum, 0.01% Sodium Azide
- Volume
- 50 Microliter
- Animal Free
- No
- Carrier-Free
- Yes
- Preservative
- Yes
- Purification Method
- Unpurified (Serum / Ascites / Supernatant)
Storage & Handling
- Storage Conditions
- Store at 4°C or -20°C. Avoid freeze-thaw cycles.
Interleukin-1beta-induced cyclooxygenase-2 expression requires activation of both c-Jun NH2-terminal kinase and p38 MAPK signal pathways in rat renal mesangial cells. Guan Z, Buckman SY, Miller BW, Springer LD, Morrison AR. The Journal of biological chemistry. 1998;273:28670-6.
PubMed: 9786861
Induction of NAD(+)-linked 15-hydroxyprostaglandin dehydrogenase expression by androgens in human prostate cancer cells. Tong M, Tai HH. Biochemical and biophysical research communications. 2000;276:77-81.
PubMed: 11006085
