LSBio
IHC-plus™ Polyclonal Rabbit anti-Human WFS1 Antibody (IHC, WB)

Human Pancreas: Formalin-Fixed, Paraffin-Embedded (FFPE)

IHC-plus™ Polyclonal Rabbit anti-Human WFS1 Antibody (IHC, WB)

Primary AntibodyLSBio Guarantee
Antibody:Rabbit Polyclonal
Applications:Immunohistochemistry (general), Immunohistochemistry, Paraffin, Western Blot
Reactivity:Human, Mouse
Format:Liquid
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$470.00each
Catalog Number: LS-B14378-50

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Overview

Description
WFS1 antibody LS-B14378 is an unconjugated rabbit polyclonal antibody to WFS1 from human. It is reactive with human and mouse. Validated for IHC and WB. Tested on 20 paraffin-embedded human tissues. Cited in 2 publications.
Application
IHC, IHC-P, WB
Reactivity
Hu, Ms
Intended Use
Research Use Only
Guarantees
This product carries the LSBio 100% Guarantee.
Category
Antibodies > Primary Antibodies > Polyclonal Antibodies
Alternative Names
DIDMOAD | DFNA14 | DFNA6 | Wolframin | WFS | WFS1 | WFSL | Wolfram syndrome 1 (wolframin) | DFNA38 | WFRS | Wolfram Syndrome 1
Recommended Dilution: IHC-P
1:200
Recommended Dilution: WB
1:500 - 1:2000
UniProt Number
O76024
SwissProt
O76024

Target

Target
WFS1
Antigen Species
Human
Specificity
Human WFS1
Epitope
Human WFS1
Gene Name
WFS1

Antibody

Host Species
Rabbit
Clonality
Polyclonal
Origin Species
Human

Immunogen

Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-285 of human WFS1 (NP_001139325.1). MDSNTAPLGPSCPQPPPAPQPQARSRLNATASLEQERSERPRAPGPQAGPGPGVRDAAAPAEPQAQHTRSRERADGTGPTKGDMEIPFEEVLERAKAGDPKAQTEVGKHYLQLAGDTDEELNSCTAVDWLVLAAKQGRREAVKLLRRCLADRRGITSENEREVRQLSSETDLERAVRKAALVMYWKLNPKKKKQVAVAELLENVGQVNEHDGGAQPGPVPKSLQKQRRMLERLVSSESKNYIALDDFVEITKKYAKGVIPSSLFLQDDEDDDELAGKSPEDLPLR
Immunogen Type
Fusion Protein (e.g., GST, MBP tag)

Format

Conjugate/Label
Unconjugated
Format
Liquid
Formulation
PBS, pH 7.3, 0.02% Sodium Azide, 50% Glycerol
Concentration
1.367 mg/mL
Volume
50 Microliter
Animal Free
No
Carrier-Free
Yes
Preservative
Yes
Purification Method
Affinity Purified

Storage & Handling

Storage Conditions
Store at -20°C. Avoid freeze-thaw cycles.
Recommended Storage Buffer
PBS

Monogenic Diabetes and Integrated Stress Response Genes Display Altered Gene Expression in Type 1 Diabetes. Helmut Hiller, Dawn E Beachy, Joseph J Lebowitz, Stefanie Engler, Justin R Mason, Douglas R Miller, Irina Kusmarteva, Laura M Jacobsen, Amanda L Posgai, Habibeh Khoshbouei, Richard A Oram, Desmond A Schatz, Andrew T Hattersley, Bernd Bodenmiller, Mark A Atkinson, Harry S Nick , Clive H Wasserfall. Diabetes. 2021 Aug;;70:1885-1897.

PubMed: 34035041 · PMC: PMC8385619


Altered cellular localisation and expression, together with unconventional protein trafficking, of prion protein, PrP C<sup>, in type 1 diabetes. Helmut Hiller, Changjun Yang, Dawn E Beachy, Irina Kusmartseva, Eduardo Candelario-Jalil, Amanda L Posgai, Harry S Nick , Desmond Schatz, Mark A Atkinson , Clive H Wasserfall. Diabetologia. 2021 Oct;;64:2279-2291.

PubMed: 34274990 · PMC: PMC8715394

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