LSBio
IHC-plus™ Polyclonal Rabbit anti-Human GRPR Antibody (Cytoplasmic Domain, IHC)

Anti-GRPR antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ Polyclonal Rabbit anti-Human GRPR Antibody (Cytoplasmic Domain, IHC)

Primary AntibodyLSBio Guarantee
Antibody:Rabbit Polyclonal
Applications:Immunohistochemistry (general)
Reactivity:Bovine, Dog, Hamster, Human, Mammal (Other), Mouse, Non-Human Primate, Pig, Rat
Format:Liquid
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$449.00each
Catalog Number: LS-A831-50

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Overview

Description
GRPR antibody LS-A831 is an unconjugated rabbit polyclonal antibody to GRPR (Cytoplasmic Domain) from human. It is reactive with human, mouse, rat and other species. Validated for IHC. Tested on 20 paraffin-embedded human tissues. Cited in 2 publications.
Application
IHC
Reactivity
Bov, Can, Ham, Hu, Mml, Ms, NHP, Por, Rt
Predicted Reactivity
Rabbit
Intended Use
Research Use Only
Guarantees
This product carries the LSBio 100% Guarantee.
Category
Antibodies > Primary Antibodies > Polyclonal Antibodies
Alternative Names
GRP-R | Bombesin BB2 receptor | GRP receptor | Grp/bombesin receptor | GRPR | grpr
Recommended Dilution: IHC-P
15 - 20 µg/ml
UniProt Number
P30550
SwissProt
P30550

Target

Target
GRPR
Antigen Species
Human
Specificity
Human GRPR. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except ADAM28 (41%).
Epitope
Human GRPR. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except ADAM28 (41%).
Gene Name
GRPR

Antibody

Host Species
Rabbit
Clonality
Polyclonal

Immunogen

Immunogen
Synthetic 17 amino acid peptide from 3rd cytoplasmic domain of human GRPR. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Hamster, Elephant, Bovine, Dog, Bat, Pig (100%); Panda, Rabbit, Opossum (94%); Horse (88%); Turkey, Chicken, Lizard (82%).
Immunogen Type
Synthetic Peptide (Linear)

Format

Conjugate/Label
Unconjugated
Format
Liquid
Formulation
PBS, 0.1% Sodium Azide
Concentration
1 mg/mL
Animal Free
No
Carrier-Free
Yes
Preservative
Yes
Purification Method
Affinity Purified

Storage & Handling

Storage Conditions
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Recommended Storage Buffer
PBS

A subpopulation of nociceptors specifically linked to itch. Han L, Ma C, Liu Q, Weng HJ, Cui Y, Tang Z, Kim Y, Nie H, Qu L, Patel KN, Li Z, McNeil B, He S, Guan Y, Xiao B, Lamotte RH, Dong X. Nature neuroscience. 2013 Feb;16:174-82.

PubMed: 23263443 · PMC: PMC3557753


Cross-inhibition of NMBR and GRPR signaling maintains normal histaminergic itch transmission. Zhao ZQ, Wan L, Liu XY, Huo FQ, Li H, Barry DM, Krieger S, Kim S, Liu ZC, Xu J, Rogers BE, Li YQ, Chen ZF. The Journal of neuroscience : the official journal of the Society for Neuroscience. Sep;34:12402-14.

PubMed: 25209280 · PMC: PMC4160775

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