Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE)

IHC-plus™ p14ARF / CDKN2A Antibody

Primary AntibodyLSBio Guarantee

Antibody:	Rabbit Polyclonal
Applications:	Immunohistochemistry (general), Immunohistochemistry, Paraffin
Format:	Liquid

$403.00each

Catalog Number: LS-A13098-50

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Description: This antibody recognizes human p14ARF. Please note that the p14ARF sequence does not overlap with p16INK4a, which is also transcribed from the same CDKN2A gene. p14ARF functions in apoptosis, autophagy and more broadly in tumor suppression via its regulation of MDM2 and p53, where loss of p14arf can inhibit p53 and contribute to survival in cancer cells (pmid: 18199527). Because CDKN2A is frequently deleted, mutated or hypermethylated in a broad range of cancers, evaluating p14ARF status via IHC can be a useful means of examining cell cycle destabilization and the breakdown of apoptosis in a given cancer.
Application: IHC, IHC-P
Intended Use: Research Use Only
Guarantees: This product carries the LSBio 100% Guarantee. ✓
Category: Antibodies > Primary Antibodies > Polyclonal Antibodies
Alternative Names: p14 | p14ARF | CDKN2 | CDKN2A | MLM | p14 arf | ARF tumor suppressor
Recommended Dilution: IHC-P: 5 µg/ml

Immunogen: Synthetic peptide within amino acids 50-100 of human p14arf (NP_478102.2)
Immunogen Type: Synthetic Peptide (Linear)

Storage Conditions: Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Recommended Storage Buffer: PBS