Monoclonal Mouse Biotin Antibody
Catalog Number: LS-C127042-200
200 µg / $755.00
Antibody: Mouse Monoclonal
Applications: Enzyme-Linked Immunosorbent Assay
Format: Liquid
Anti-TRF1 antibody IHC of human uterus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
IHC-plus™ Monoclonal Mouse anti-Human TRF1 / TERF1 Antibody (clone BED5, IHC)
Primary AntibodyLSBio Guarantee
| Antibody: | Mouse Monoclonal |
| Applications: | Enzyme-Linked Immunosorbent Assay, Immunohistochemistry (general), Immunohistochemistry, Frozen, Immunohistochemistry, Paraffin |
| Reactivity: | Human |
| Format: | Liquid |
$470.00each
Catalog Number: LS-B5949-50
Catalog Number: LS-B5949
For bulk orders or custom formulations:
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- Description
- TERF1 antibody LS-B5949 is an unconjugated mouse monoclonal antibody to human TERF1 (TRF1). Validated for ELISA and IHC. Tested on 20 paraffin-embedded human tissues.
- Application
- ELISA, IHC, IHC-F, IHC-P
- Reactivity
- Hu
- Intended Use
- Research Use Only
- Guarantees
- This product carries the LSBio 100% Guarantee. ✓
- Category
- Antibodies > Primary Antibodies > Monoclonal Antibodies
- Alternative Names
- HTRF1-AS | NIMA-interacting protein 2 | PIN2 | Telomeric protein Pin2/TRF1 | TRBF1 | TTAGGG repeat-binding factor 1 | T-TRF1 | TERF1 | TRF | TRF1
- Recommended Dilution: IHC-P
- 10 µg/ml
- UniProt Number
- P54274
- NCBI GenBank
- NM_017489 | NP_059523.2
- SwissProt
- P54274
Target
- Target
- TRF1 / TERF1
- Antigen Species
- Human
- Specificity
- Recognizes TTAGGG repeat binding factor 1 (TRF1) a ubiquitously expressed 60kD protein. Along with tankyrase-1, TIN2, and PINX1, TRF1 binds the double-stranded TTAGGG repeat of telomeres and regulates telomere length. Protection of telomeres-1 (POT1) is a single-stranded telomeric DNA-binding protein which controls the elongation of telomeres by telomerase. TRF1 mediates the loading of POT1 onto single stranded DNA, conveying information about telomere length to the telomere terminus, where telomerase is regulated. If the telomere is long enough, telomerase is inhibited. Additionally in conjunction with POT1 and TTAGGG repeat binding factor 1 (TRF2), TRF1 recruits factors to the telomere, inducing the formation of the protective t-loop. TRF1 along with TRF2, POT1, TIN2, TPP1, and Rap1 form the shelterin complex which distinguishes telomeres from sites of DNA damage. Reported to work in Western blotting applications.
- Epitope
- Recognizes TTAGGG repeat binding factor 1 (TRF1) a ubiquitously expressed 60kD protein. Along with tankyrase-1, TIN2, and PINX1, TRF1 binds the double-stranded TTAGGG repeat of telomeres and regulates telomere length. Protection of telomeres-1 (POT1) is a single-stranded telomeric DNA-binding protein which controls the elongation of telomeres by telomerase. TRF1 mediates the loading of POT1 onto single stranded DNA, conveying information about telomere length to the telomere terminus, where telomerase is regulated. If the telomere is long enough, telomerase is inhibited. Additionally in conjunction with POT1 and TTAGGG repeat binding factor 1 (TRF2), TRF1 recruits factors to the telomere, inducing the formation of the protective t-loop. TRF1 along with TRF2, POT1, TIN2, TPP1, and Rap1 form the shelterin complex which distinguishes telomeres from sites of DNA damage. Reported to work in Western blotting applications.
- Gene Name
- TERF1
Antibody
- Host Species
- Mouse
- Clonality
- Monoclonal
- Clone
- BED5
- Origin Species
- Human
Immunogen
- Immunogen
- Recombinant TRF1
Format
- Conjugate/Label
- Unconjugated
- Format
- Liquid
- Formulation
- PBS, 0.09% Sodium Azide
- Concentration
- 1 mg/mL
- Animal Free
- No
- Carrier-Free
- Yes
- Preservative
- Yes
- Purification Method
- Affinity Purified
Storage & Handling
- Storage Conditions
- Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
- Recommended Storage Buffer
- PBS