Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)

IHC-plus™ Mitofusin 2 / MFN2 Antibody

Primary AntibodyLSBio Guarantee

Antibody:	Rabbit Polyclonal
Applications:	Enzyme-Linked Immunosorbent Assay, Immunohistochemistry (general), Immunohistochemistry, Paraffin
Reactivity:	Human
Format:	Liquid

See all Mitofusin 2 / MFN2 antibodies â†’

$383.00each

Catalog Number: LS-B15154-50

Unit Size

Quantity

For bulk orders or custom formulations:

Overview

Description: MFN2 antibody LS-B15154 is an unconjugated rabbit polyclonal antibody to human MFN2 (Mitofusin 2). Validated for ELISA and IHC. Tested on 20 paraffin-embedded human tissues.
Application: ELISA, IHC, IHC-P
Reactivity: Hu
Intended Use: Research Use Only
Guarantees: This product carries the LSBio 100% Guarantee. ✓
Category: Antibodies > Primary Antibodies > Polyclonal Antibodies
Alternative Names: CMT2A2 | CMT2A | CPRP1 | Hyperplasia suppressor | MARF | Mitofusin 2 | MFN2 | HSG | Transmembrane GTPase MFN2 | KIAA0214 | Mitofusin-2
Recommended Dilution: IHC-P: 1:100 - 1:200
UniProt Number: O95140
NCBI GenBank: NM_014874 | NP_055689.1
SwissProt: O95140

Target

Target: Mitofusin 2 / MFN2
Antigen Species: Human
Specificity: Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN2 acts independently of the cytoskeleton. It therefore plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes. Overexpression induces the formation of mitochondrial networks. Plays an important role in the regulation of vascular smooth muscle cell proliferation. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). Is required for PARK2 recruitment to dysfunctional mitochondria. Involved in the control of unfolded protein response (UPR) upon ER stress including activation of apoptosis and autophagy during ER stress. Acts as an upstream regulator of EIF2AK3 and suppresses EIF2AK3 activation under basal conditions.
Epitope: Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN2 acts independently of the cytoskeleton. It therefore plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes. Overexpression induces the formation of mitochondrial networks. Plays an important role in the regulation of vascular smooth muscle cell proliferation. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). Is required for PARK2 recruitment to dysfunctional mitochondria. Involved in the control of unfolded protein response (UPR) upon ER stress including activation of apoptosis and autophagy during ER stress. Acts as an upstream regulator of EIF2AK3 and suppresses EIF2AK3 activation under basal conditions.
Gene Name: MFN2