Anti-ITPR1 antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.

IHC-plus™ ITPR1 / IP3 Receptor Type 1 Antibody (aa1892-1911)

Primary AntibodyLSBio Guarantee

Antibody:	Rabbit Polyclonal
Applications:	Immunocytochemistry, Immunohistochemistry (general), Immunohistochemistry, Frozen, Immunohistochemistry, Paraffin, Immunoprecipitation, Western Blot
Reactivity:	Bovine, Human, Mouse, Non-Human Primate, Rat
Format:	Liquid

See all ITPR1 / IP3 Receptor Type 1 antibodies â†’

$495.00each

Catalog Number: LS-B2640-50

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Overview

Description: IP3 Receptor Type 1 antibody LS-B2640 is an unconjugated rabbit polyclonal antibody to IP3 Receptor Type 1 (ITPR1) (aa1892-1911) from human. It is reactive with human, mouse, rat and other species. Validated for ICC, IHC, IP and WB. Tested on 20 paraffin-embedded human tissues. Cited in 1 publication.
Application: ICC, IHC, IHC-F, IHC-P, IP, WB
Reactivity: Bov, Hu, Ms, NHP, Rt
Intended Use: Research Use Only
Guarantees: This product carries the LSBio 100% Guarantee. ✓
Category: Antibodies > Primary Antibodies > Polyclonal Antibodies
Alternative Names: InsP3R-I | IP3R1 | InsP3R | InsP3R type I | INSP3R1 | IP3R | Opisthotonus | Pcp1 | IP3 receptor | IP3 receptor isoform 1 | ITPR1 | SCA15 | Spinocerebellar ataxia 15 | Spinocerebellar ataxia 16 | I145TR | IP3R 1 | KIAA1754 | SCA16 | Type 1 InsP3 receptor
Recommended Dilution: IHC-F: 1:125
Recommended Dilution: IHC-P: 5 µg/ml
Recommended Dilution: WB: 1:500
UniProt Number: Q14643
NCBI GenBank: NM_001099952 | NP_002213.5
SwissProt: Q14643

Target

Target: ITPR1 / IP3 Receptor Type 1
Antigen Species: Human
Specificity: Recognizes human IP3R-I. Detects a band of ~240kD by Western Blot. Species cross-reactivity: mouse, rat and canine.
Epitope: Recognizes human IP3R-I. Detects a band of ~240kD by Western Blot. Species cross-reactivity: mouse, rat and canine.
Gene Name: ITPR1

Antibody

Host Species: Rabbit
Clonality: Polyclonal
Origin Species: Human

Immunogen

Immunogen: Synthetic peptide corresponding to aa 1892-1911 (N1892KKKDDEVDRDAPSRKKAKE1911) of the cytoplasmic C-Terminus domain of human IP3R-I (inositol 1,4,5-triphosphate receptor (type-I)). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Bovine (100%); Hamster, Elephant, Panda, Horse (95%); Opossum (85%).
Immunogen Type: Synthetic Peptide (Linear)

Format

Conjugate/Label: Unconjugated
Format: Liquid
Formulation: PBS, 1 mg/ml BSA, 0.05% Sodium Azide
Concentration: 1.3 mg/mL
Volume: 50 Microliter
Animal Free: No
Carrier-Free: No
Preservative: Yes
Purification Method: Affinity Purified

Storage & Handling

Storage Conditions: Store at 4°C or -20°C. Avoid freeze-thaw cycles.
Recommended Storage Buffer: PBS

PC-PLC is involved in osteoclastogenesis induced by TNF- alpha through upregulating IP3R1 expression. Xia L, Zhang D, Wang C, Wei F, Hu Y. FEBS letters. 2012 Sep;586:3341-8. PubMed: 22819818

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