LSBio
IHC-plus™ HLA-A2 Antibody (clone BB7.2, Low Endotoxin)

Anti-HLA-A2 antibody IHC staining of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. This image was taken for the unmodified form of this product. Other forms have not been tested.

IHC-plus™ HLA-A2 Antibody (clone BB7.2, Low Endotoxin)

Primary AntibodyLSBio Guarantee
Antibody:Mouse Monoclonal
Applications:Flow Cytometry, Immunohistochemistry (general), Immunohistochemistry, Frozen, Immunohistochemistry, Paraffin, Immunoprecipitation
Reactivity:Human
Format:Liquid
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$567.00each
Catalog Number: LS-B10938-0.25

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Overview

Description
HLA-A2 antibody LS-B10938 is an unconjugated mouse monoclonal antibody to human HLA-A2. Validated for Flow, IHC and IP. Tested on 20 paraffin-embedded human tissues.
Application
FC, IHC, IHC-F, IHC-P, IP
Reactivity
Hu
Intended Use
Research Use Only
Guarantees
This product carries the LSBio 100% Guarantee. ✓
Category
Antibodies > Primary Antibodies > Monoclonal Antibodies
Recommended Dilution: FC
10 µg/ml
Recommended Dilution: IHC-P
10 µg/ml

Target

Target
HLA-A2
Antigen Species
Human
Specificity
Recognizes the human HLA A2 histocompatibility antigen. The epitope recognized by this has been studied extensively and would appear to include the C-terminus of the alpha-2 helix and a turn on one of the underlying beta strands. The antibody may be used for the flow cytometric detection of HLA A2 expression and has also been used for immunoaffinity purification of HLA A2 molecules. Functionally this is reported to inhibit MHC restricted cellular cytotoxicity
Epitope
The major histocompatibility complex (MHC) is a cluster of genes that are important in the immune response to infections. In humans, this complex is referred to as the human leukocyte antigen (HLA) region. There are 3 major MHC class I proteins encoded by the HLA which are HLA A, HLA B and HLA C. The HLA A gene is part of the human HLA complex on chromosome 6 and there are a large number of variant alleles of this gene. The antibody recognizes the human HLA A2 histocompatability antigen. The epitope recognized by this has been studied extensively and would appear to include the carboxy-terminus of the alpha-2 helix and a turn on one of the underlying beta strands. The antibody may be used for the flow cytometric detection of HLA A2 expression and has also been used for immunoaffinity purification of HLA A2 molecules. Functionally this is reported to inhibit MHC restricted cellular cytotoxicity. The antibody recognizes A2 and A28 others not tested.

Antibody

Host Species
Mouse
Clonality
Monoclonal
Clone
BB7.2

Immunogen

Immunogen
Papain solubilized HLA-A2.

Format

Conjugate/Label
Unconjugated
Format
Liquid
Formulation
PBS, No preservatives added
Concentration
1 mg/mL
Animal Free
No
Carrier-Free
Yes
Preservative
No
Purification Method
Protein G Affinity

Storage & Handling

Storage Conditions
Store at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
Recommended Storage Buffer
PBS

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To request an SDS/MSDS form for this product, please contact our Technical Support department at: technical@vectorlabs.com.