CASP6 / Caspase 6 Antibody
Catalog Number: LS-C813297
3 sizes / from $301.00
Antibody: Rabbit Polyclonal
Applications: Enzyme-Linked Immunosorbent Assay, Western Blot
Reactivity: Human, Mouse, Rat
Format: Liquid
Anti-Caspase 6 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
IHC-plus™ CASP6 / Caspase 6 Antibody
Primary AntibodyLSBio Guarantee
| Antibody: | Rabbit Polyclonal |
| Applications: | Enzyme-Linked Immunosorbent Assay, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (general), Immunohistochemistry, Paraffin, Western Blot |
| Reactivity: | Human |
| Format: | Liquid |
$383.00each
Catalog Number: LS-B477-50
Catalog Number: LS-B477
For bulk orders or custom formulations:
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- Description
- Caspase 6 antibody LS-B477 is an unconjugated rabbit polyclonal antibody to human Caspase 6 (CASP6). Validated for ELISA, ICC, IF, IHC and WB. Tested on 20 paraffin-embedded human tissues. Cited in 3 publications.
- Application
- ELISA, ICC, IF, IHC, IHC-P, WB
- Reactivity
- Hu
- Nonreactive Species
- Mouse, Rat
- Intended Use
- Research Use Only
- Guarantees
- This product carries the LSBio 100% Guarantee. ✓
- Category
- Antibodies > Primary Antibodies > Polyclonal Antibodies
- Alternative Names
- Apoptotic protease Mch-2 | CASP6 | Caspase 6 | CASP-6 | Caspase-6 | Mch-2 | MCH2
- Recommended Dilution: IHC-P
- 2.5 µg/ml
- Recommended Dilution: WB
- 1 µg/ml
- UniProt Number
- P55212
- NCBI GenBank
- NM_001226 | NP_001217.2
- SwissProt
- P55212
Target
- Target
- CASP6 / Caspase 6
- Antigen Species
- Human
- Specificity
- Depending on cell lines or tissues used, either full-length or other cleavage products may be observed.
- Epitope
- Depending on cell lines or tissues used, either full-length or other cleavage products may be observed.
- Gene Name
- CASP6
Antibody
- Host Species
- Rabbit
- Clonality
- Polyclonal
- Origin Species
- Human
Immunogen
- Immunogen
- A 15 AA synthetic peptide near the center of human Caspase-6. The immunogen is located within aa 160-210 of Caspase-6.
- Immunogen Type
- Synthetic Peptide (Linear)
Format
- Conjugate/Label
- Unconjugated
- Format
- Liquid
- Formulation
- PBS containing 0.02% Sodium Azide
- Concentration
- 1 mg/mL
- Animal Free
- No
- Carrier-Free
- Yes
- Preservative
- Yes
- Purification Method
- Affinity Purified
Storage & Handling
- Storage Conditions
- Store at 4°C for up 3 months. Store at -20°C for up to 1 year. Avoid freeze/thaw cycles.
- Recommended Storage Buffer
- PBS
Caspase-6 activity in the CA1 region of the hippocampus induces age-dependent memory impairment. LeBlanc AC, Ramcharitar J, Afonso V, Hamel E, Bennett DA, Pakavathkumar P, Albrecht S. Cell death and differentiation. 2014;21:696-706.
PubMed: 24413155 · PMC: PMC3978300
Methylene blue inhibits Caspase-6 activity, and reverses Caspase-6-induced cognitive impairment and neuroinflammation in aged mice. Libin Zhou, Joseph Flores, Anastasia Noël, Olivier Beauchet, P Jesper Sjöström, Andrea C LeBlanc. Acta neuropathologica communications. 2019 Dec;7:210.
PubMed: 31843022 · PMC: PMC6915996
Caspase-6-cleaved Tau fails to induce Tau hyperphosphorylation and aggregation, neurodegeneration, glial inflammation, and cognitive deficits. Anastasia Noël , Bénédicte Foveau , Andréa C LeBlanc. Cell death & disease. 2021 Mar;12:227.
PubMed: 33649324 · PMC: PMC7921451
