LSBio
IHC-plus™ C5AR1 / CD88 / C5a Receptor Antibody (clone 10/92)

Anti-C5AR1 / CD88 antibody IHC of mouse kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.

IHC-plus™ C5AR1 / CD88 / C5a Receptor Antibody (clone 10/92)

Primary AntibodyLSBio Guarantee
Antibody:Rat Monoclonal
Applications:Flow Cytometry, Immunofluorescence, Immunohistochemistry (general), Immunohistochemistry, Frozen, Immunohistochemistry, Paraffin
Reactivity:Mouse
Format:Liquid
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$470.00each
Catalog Number: LS-B5229-0.05

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Overview

Description
C5a Receptor antibody LS-B5229 is an unconjugated rat monoclonal antibody to mouse C5a Receptor (C5AR1 / CD88). Validated for Flow, IF and IHC. Cited in 1 publication.
Application
FC, IF, IHC, IHC-F, IHC-P
Reactivity
Ms
Intended Use
Research Use Only
Guarantees
This product carries the LSBio 100% Guarantee. ✓
Category
Antibodies > Primary Antibodies > Monoclonal Antibodies
Alternative Names
C5A | C5a-R | C5a ligand | C5a receptor | CD88 | C5a anaphylatoxin receptor | C5AR | C5AR1 | C5R1 | CD88 antigen
Recommended Dilution: FC
1:50 - 1:100
Recommended Dilution: IHC-P
10 µg/ml
UniProt Number
P21730
NCBI GenBank
NM_001736 | NP_001727.1
SwissProt
P21730

Target

Target
C5AR1 / CD88 / C5a Receptor
Antigen Species
Mouse
Specificity
Recognizes murine CD88, a 45kD G-protein coupled cell surface receptor, which is otherwise known as C5aR. The CD88 molecule functions as a receptor for the complement component C5a, which is a potent proinflammatory molecule and a chemoattractant for neutrophils to sites of infection. In mouse, CD88 is expressed on granulocytes, monocytes and macrophages but not on resting or stimulated lymphocytes. Clone 10/92 does not block the binding of the C5a to murine CD88
Epitope
Recognizes murine CD88, a 45kD G-protein coupled cell surface receptor, which is otherwise known as C5aR. The CD88 molecule functions as a receptor for the complement component C5a, which is a potent proinflammatory molecule and a chemoattractant for neutrophils to sites of infection. In mouse, CD88 is expressed on granulocytes, monocytes and macrophages but not on resting or stimulated lymphocytes. Clone 10/92 does not block the binding of the C5a to murine CD88.
Gene Name
C5AR1

Antibody

Host Species
Rat
Clonality
Monoclonal
Clone
10/92
Origin Species
Human

Immunogen

Immunogen
RBL-2H3 transfected cells expressing murine C5aR

Format

Conjugate/Label
Unconjugated
Format
Liquid
Formulation
PBS, 0.09% Sodium Azide
Concentration
1 mg/mL
Animal Free
No
Carrier-Free
Yes
Preservative
Yes
Purification Method
Protein G Affinity

Storage & Handling

Storage Conditions
Short term: store at 4°C. Long term: aliquot and store at -20°C. Avoid freeze-thaw cycles.
Recommended Storage Buffer
PBS
Deletion of Biliverdin Reductase A in Myeloid Cells Promotes Chemokine Expression and Chemotaxis in Part via a Complement C5a--C5aR1 Pathway. Kavita Bisht, Giacomo Canesin, Tasneem Cheytan, Mailin Li, Zsuzsanna Nemeth, Eva Csizmadia, Trent M Woodruff, David E Stec, Andrew C Bulmer, Leo E Otterbein, Barbara Wegiel. Journal of immunology (Baltimore, Md. : 1950). 2019 May;202:2982-2990. PubMed: 30952817 PMC: PMC6504595
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