Anti-ACVR1 antibody IHC of human skeletal muscle, vessel. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.

IHC-plus™ ALK2 / ACVR1 Antibody (aa496-509)

Primary AntibodyLSBio Guarantee

Antibody:	Rabbit Polyclonal
Applications:	Immunohistochemistry (general), Immunohistochemistry, Paraffin, Western Blot
Reactivity:	Bovine, Dog, Hamster, Horse, Human, Mammal (Other), Mouse, Non-Human Primate, Pig, Rabbit, Rat, Xenopus
Format:	Liquid

$383.00each

Catalog Number: LS-B2010-50

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Quantity

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Overview

Description: ACVR1 antibody LS-B2010 is an unconjugated rabbit polyclonal antibody to ACVR1 (ALK2) (aa496-509) from human. It is reactive with human, mouse, rat and other species. Validated for IHC and WB. Tested on 20 paraffin-embedded human tissues. Cited in 1 publication.
Application: IHC, IHC-P, WB
Reactivity: Bov, Can, Ham, Hr, Hu, Mml, Ms, NHP, Por, Rb, Rt, Xen
Predicted Reactivity: Chicken
Intended Use: Research Use Only
Guarantees: This product carries the LSBio 100% Guarantee. ✓
Category: Antibodies > Primary Antibodies > Polyclonal Antibodies
Alternative Names: Activin A receptor type I | Activin A receptor, type I | ACTR-I | ActRIA | ACVR1A | ALK2 | Activin receptor-like kinase 2 | Activin receptor type-1 | ACTRI | ACVR1 | ACVRLK2 | ALK-2 | Activin receptor type I | Actr1 | FOP | Hydroxyalkyl-protein kinase | SKR1 | TSRI | TSR-I | Tsk7L
Recommended Dilution: IHC-P: 10 µg/ml
Recommended Dilution: WB: 3 - 5 µg/ml
UniProt Number: Q04771
NCBI GenBank: NM_001105 | NP_001096.1
SwissProt: Q04771

Target

Target: ALK2 / ACVR1
Antigen Species: Human
Specificity: A portion of amino acids 475-509 of human ACVR1 was used as the immunogen.
Epitope: In human kidney, additional bands are seen at approximately 27 and 14 kD.
Gene Name: ACVR1

Antibody

Host Species: Rabbit
Clonality: Polyclonal
Origin Species: Human

Immunogen

Immunogen: A synthetic peptide corresponding to amino acids 496-509 (TKIDNSLDKLKTDC) of amino acids 475-525 of human ACVR1, GenBank NP 001096. Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Hamster, Elephant, Panda, Dog, Bat, Bovine, Horse, Rabbit, Pig, Xenopus (100%); Opossum, Turkey, Chicken, Platypus, Salmon (93%); Stickleback, Pufferfish (86%).
Immunogen Type: Synthetic Peptide (Linear)

Format

Conjugate/Label: Unconjugated
Format: Liquid
Formulation: PBS, 0.05% Sodium Azide, 0.2% Gelatin
Concentration: 0.5 mg/mL
Animal Free: No
Carrier-Free: Yes
Preservative: Yes
Purification Method: Protein G Affinity

Storage & Handling

Storage Conditions: Short term: store at 4°C. Long term: store at -20°C. Avoid freeze-thaw cycles.
Recommended Storage Buffer: PBS

Coco is a dual activity modulator of TGFß signaling. Deglincerti A, Haremaki T, Warmflash A, Sorre B, Brivanlou AH. Development (Cambridge, England). 2015;142:2678-85. PubMed: 26116664 PMC: PMC4529031

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