ADAM8 Antibody
Catalog Number: LS-C659621-100
100 µg / $338.00
Antibody: Rabbit Polyclonal
Applications: Enzyme-Linked Immunosorbent Assay, Immunohistochemistry (general), Western Blot
Reactivity: Human
Format: Liquid
Anti-ADAM8 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.
IHC-plus™ ADAM8 Antibody
Primary AntibodyLSBio Guarantee
| Antibody: | Rabbit Polyclonal |
| Applications: | Immunohistochemistry (general), Immunohistochemistry, Paraffin, Western Blot |
| Reactivity: | Human |
| Format: | Liquid |
$470.00each
Catalog Number: LS-B4068-50
Catalog Number: LS-B4068
For bulk orders or custom formulations:
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- Description
- ADAM8 antibody LS-B4068 is an unconjugated rabbit polyclonal antibody to human ADAM8. Validated for IHC and WB. Tested on 20 paraffin-embedded human tissues. Cited in 3 publications.
- Application
- IHC, IHC-P, WB
- Reactivity
- Hu
- Intended Use
- Research Use Only
- Guarantees
- This product carries the LSBio 100% Guarantee. ✓
- Category
- Antibodies > Primary Antibodies > Polyclonal Antibodies
- Alternative Names
- ADAM metallopeptidase domain 8 | ADAM8 | Cell surface antigen MS2 | ADAM 8 | MS2 | CD156 | CD156a antigen
- Recommended Dilution: IHC-P
- 20 µg/ml
- Recommended Dilution: WB
- 1:500 - 1:3000
- UniProt Number
- P78325
- NCBI GenBank
- NM_001109 | NP_001100.3
- SwissProt
- P78325
Target
- Target
- ADAM8
- Antigen Species
- Human
- Specificity
- Human ADAM8.
- Epitope
- Human ADAM8.
- Gene Name
- ADAM8
Antibody
- Host Species
- Rabbit
- Clonality
- Polyclonal
- Origin Species
- Human
Immunogen
- Immunogen
- Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human ADAM8. The exact sequence is proprietary.
- Immunogen Type
- Synthetic Peptide (Linear)
Format
- Conjugate/Label
- Unconjugated
- Format
- Liquid
- Formulation
- 1X PBS, pH 7, 0.01% Thimerosal, 20% Glycerol
- Concentration
- 1 mg/mL
- Volume
- 50 Microliter
- Animal Free
- No
- Carrier-Free
- Yes
- Preservative
- Yes
- Purification Method
- Affinity Purified
Storage & Handling
- Storage Conditions
- Store as concentrated solution. Centrifuge briefly prior to opening vial. For short term storage (1-2 weeks), store at 4°C. For long term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
- Recommended Storage Buffer
- 1X PBS
ADAM8 expression in invasive breast cancer promotes tumor dissemination and metastasis. Romagnoli M, Mineva ND, Polmear M, Conrad C, Srinivasan S, Loussouarn D, Barillé-Nion S, Georgakoudi I, Dagg Á, McDermott EW, Duffy MJ, McGowan PM, Schlomann U, Parsons M, Bartsch JW, Sonenshein GE. EMBO molecular medicine. 2014 Feb;6:278-294.
PubMed: 24375628 · PMC: PMC3927960
N-glycosylation regulates ADAM8 processing and activation. Srinivasan S, Romagnoli M, Bohm A, Sonenshein GE. The Journal of biological chemistry. 2014;289:33676-88.
PubMed: 25336660 · PMC: PMC4246118
miR-720 is a downstream target of an ADAM8-induced ERK signaling cascade that promotes the migratory and invasive phenotype of triple-negative breast cancer cells. Das SG, Romagnoli M, Mineva ND, Barillé-Nion S, Jézéquel P, Campone M, Sonenshein GE. Breast cancer research : BCR. 2016;18:40.
PubMed: 27039296 · PMC: PMC4818899
