ADAM17 / TACE Antibody
Catalog Number: LS-C815824-100
100 µL / $309.00
Antibody: Rabbit Polyclonal
Applications: Immunohistochemistry, Paraffin
Reactivity: Human
Format: Liquid
Anti-ADAM17 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
IHC-plus™ ADAM17 / TACE Antibody (clone 1F6)
Primary AntibodyLSBio Guarantee
| Antibody: | Mouse Monoclonal |
| Applications: | Immunohistochemistry (general) |
| Reactivity: | Human |
| Format: | Liquid |
$383.00each
Catalog Number: LS-B4426-50
Catalog Number: LS-B4426
For bulk orders or custom formulations:
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- Description
- TACE antibody LS-B4426 is an unconjugated mouse monoclonal antibody to human TACE (ADAM17). Validated for ELISA, IHC, PLA and WB. Tested on 20 paraffin-embedded human tissues. Cited in 1 publication.
- Application
- IHC
- Reactivity
- Hu
- Intended Use
- Research Use Only
- Guarantees
- This product carries the LSBio 100% Guarantee. ✓
- Category
- Antibodies > Primary Antibodies > Monoclonal Antibodies
- Alternative Names
- CD156B | CD156b antigen | CSVP | ADAM 17 | ADAM17 | NISBD | TNF-alpha converting enzyme | TNF-alpha convertase | TNF-alpha-converting enzyme | Snake venom-like protease | TACE
- Recommended Dilution: IHC-P
- 5 µg/ml
- Recommended Dilution: WB
- 1:500 - 1:1000
- UniProt Number
- P78536
- NCBI GenBank
- NM_003183 | NP_003174.3
- SwissProt
- P78536
Target
- Target
- ADAM17 / TACE
- Antigen Species
- Human
- Gene Name
- ADAM17
Antibody
- Host Species
- Mouse
- Clonality
- Monoclonal
- Clone
- 1F6
- Light Chain
- Kappa Light Chain
- Origin Species
- Human
Immunogen
- Immunogen
- ADAM17 (NP_003174, 215 aa ~ 315 aa) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Format
- Conjugate/Label
- Unconjugated
- Format
- Liquid
- Formulation
- PBS, pH 7.4
- Concentration
- 1 mg/mL
- Animal Free
- No
- Carrier-Free
- Yes
- Purification Method
- Protein A Affinity
Storage & Handling
- Storage Conditions
- Store at -20°C. Aliquot to avoid freeze/thaw cycles.
- Recommended Storage Buffer
- PBS
ADAM10 and ADAM17 cleave PD-L1 to mediate PD-(L)1 inhibitor resistance. Jacob J Orme, Khalid A Jazieh, Tiancheng Xie, Susan Harrington, Xin Liu, Matthew Ball, Benjamin Madden, M Cristine Charlesworth, Tariq U Azam, Fabrice Lucien, Bharath Wootla, Yanli Li, Jose Caetano Villasboas, Aaron S Mansfield, Roxana S Dronca, Haidong Dong. Oncoimmunology. 2020 May;9:1744980. PubMed: 32363112 PMC: PMC7185206
