Anti-HUWE1 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
HUWE1 / ARFBP1 Antibody
| Antibody: | Rabbit Polyclonal |
| Applications: | Enzyme-Linked Immunosorbent Assay, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (general), Immunohistochemistry, Paraffin, Western Blot |
| Reactivity: | Human, Mouse, Rat |
| Format: | Liquid |
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- Description
- ARFBP1 antibody LS-B1359 is an unconjugated rabbit polyclonal antibody to ARFBP1 (HUWE1) from human. It is reactive with human, mouse and rat. Validated for ELISA, ICC, IF, IHC and WB. Cited in 6 publications.
- Application
- ELISA, ICC, IF, IHC, IHC-P, WB
- Reactivity
- Hu, Ms, Rt
- Intended Use
- Research Use Only
- Guarantees
- This product carries the LSBio 100% Guarantee. ✓
- Category
- Antibodies > Primary Antibodies > Polyclonal Antibodies
- Alternative Names
- ARF-binding protein 1 | ARF-BP1 | BJ-HCC-24 tumor antigen | HUWE1 | Ib772 | KIAA0312 | LASU1 | Mcl-1 ubiquitin ligase E3 | HECTH9 | MULE | HSPC272 | KIAA1578 | URE-B1 | UREB1 | URE-binding protein 1 | HECT domain protein LASU1 | Large structure of UREB1
- Recommended Dilution: IHC-P
- 5 µg/ml
- Recommended Dilution: WB
- 2 µg/ml
- UniProt Number
- Q7Z6Z7
- NCBI GenBank
- NM_031407 | NP_113584.3
- SwissProt
- Q7Z6Z7
Target
- Target
- HUWE1 / ARFBP1
- Antigen Species
- Human
- Gene Name
- HUWE1
Antibody
- Host Species
- Rabbit
- Clonality
- Polyclonal
- Origin Species
- Human
Immunogen
- Immunogen
- A 19 AA synthetic peptide near the C-Terminus of human ARF-BP1. The immunogen is located within aa 4250-4300 of ARF-BP1.
- Immunogen Type
- Synthetic Peptide (Linear)
Format
- Conjugate/Label
- Unconjugated
- Format
- Liquid
- Formulation
- PBS containing 0.02% Sodium Azide
- Concentration
- 1 mg/mL
- Animal Free
- No
- Carrier-Free
- Yes
- Preservative
- Yes
- Purification Method
- Affinity Purified
Storage & Handling
- Storage Conditions
- Store at 4°C for up to 1 year.
- Recommended Storage Buffer
- PBS
Obesity promotes liver carcinogenesis via Mcl-1 stabilization independent of IL-6R alpha signaling. Gruber S, Straub BK, Ackermann PJ, Wunderlich CM, Mauer J, Seeger JM, B[Character fc]ning H, Heukamp L, Kashkar H, Schirmacher P, Br[Character fc]ning JC, Wunderlich FT. Cell reports. 2013 Aug;4:669-80.
PubMed: 23954788
Huwe1 interacts with Gadd45b under oxygen-glucose deprivation and reperfusion injury in primary Rat cortical neuronal cells. He GQ, Xu WM, Li JF, Li SS, Liu B, Tan XD, Li CQ. Molecular brain. 2015;8:88.
PubMed: 26698301 · PMC: PMC4690333
HUWE1 plays important role in mouse preimplantation embryo development and the dysregulation is associated with poor embryo development in humans. Chen LJ, Xu WM, Yang M, Wang K, Chen Y, Huang XJ, Ma QH. Scientific reports. 2016;6:37928.
PubMed: 27901130 · PMC: PMC5128802
HUWE1 mediates inflammasome activation and promotes host defense against bacterial infection. Yu Guo, Longjun Li, Tao Xu, Xiaomin Guo, Chaoming Wang, Yihui Li, Yanan Yang, Dong Yang, Bin Sun, Xudong Zhao, Genze Shao, Xiaopeng Qi. The Journal of clinical investigation. 2020 December;130:6301-6316.
PubMed: 33104527 · PMC: PMC7685759
Associations between Huwe1 and autophagy in rat cerebral neuron oxygen-glucose deprivation and reperfusion injury. Guo-Qian He, Yan Chen, Hui-Juan Liao, Wen-Ming Xu, Wei Zhang, Guo-Lin He. Molecular medicine reports. 2020 December;22:5083-5094.
PubMed: 33173969 · PMC: PMC7646962
Silencing Huwe1 reduces apoptosis of cortical neurons exposed to oxygen-glucose deprivation and reperfusion. Guo-Qian He, Wen-Ming Xu, Hui-Juan Liao, Chuan Jiang, Chang-Qing Li, Wei Zhang. Neural regeneration research. 2019 Nov;14:1977-1985.
PubMed: 31290456 · PMC: PMC6676871