GJB3 / CX31 / Connexin 31 Antibody (phospho-Ser368)
Primary AntibodyLSBio Guarantee
| Antibody: | Rabbit Monoclonal |
| Applications: | Western Blot |
| Reactivity: | Rat |
| Format: | Liquid |
$553.00each
Catalog Number: LS-C43142-0.1
Catalog Number: LS-C43142
For bulk orders or custom formulations:
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- Description
- Connexin 31 antibody LS-C43142 is an unconjugated rabbit monoclonal antibody to rat Connexin 31 (GJB3 / CX31) (pSer368). Validated for WB.
- Application
- WB
- Reactivity
- Rt
- Intended Use
- Research Use Only
- Guarantees
- This antibody carries the LSBio 100% Guarantee. ✓
- Category
- Antibodies > Primary Antibodies > Monoclonal Antibodies
- Alternative Names
- Connexin 31 | Connexin-31 | CX31 | DFNA2 | Erythrokeratodermia variabilis | Gap junction beta-3 protein | GJB3 | DFNA2B | EKV | Gap junction protein beta 3
- Recommended Dilution: WB
- 1:1000
- UniProt Number
- O75712
- NCBI GenBank
- NM_024009 | NP_076872.1
- SwissProt
- O75712
Target
- Target
- Rat GJB3 / CX31 / Connexin 31
- Antigen Species
- Rat
- Epitope
- Recognizes the ~43 kD Connexin43, when phosphorylated at Ser368. Connexin43 (CX43) allows for the exchange of solutions between neighboring cells through the formation of gap-junctional channels and is expressed in the brain, kidneys and myocardium, as well as vascular endothelial cells. A decrease in the permeability of gap-junctional channels occurs due to a conformational change in the structure of CX43, and that this is mediated by the phosphorylation of CX43 at residue Ser368, by Protein Kinase C. A possible link between CX43 and epilepsy has been investigated following the detection of high levels of CX43 in both low-grade tumors and peritumoural reactive astrocytes.
- Gene Name
- GJB3
Antibody
- Host Species
- Rabbit
- Clonality
- Monoclonal
- Isotype
- IgG
Immunogen
- Immunogen
- Synthetic phosphopeptide corresponding to an amino acid sequence within connexin43 which includes phosphorylated Ser368 (pSer368).
- Immunogen Type
- Synthetic Peptide (Linear)
Format
- Conjugate/Label
- Unconjugated
- Format
- Liquid
- Formulation
- 10mM HEPES, pH 7.5, 0.05% Sodium Azide, 50% Glycerol, 0.01% BSA
- Volume
- 0.1 Milliliter
- Preservative
- Yes
- Purification Method
- Other
Storage & Handling
- Storage Conditions
- Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
- Recommended Storage Buffer
- 10mM HEPES