ESR2 / ER Beta Antibody (aa493-504, clone 5/25)
Primary AntibodyLSBio Guarantee
| Antibody: | Mouse Monoclonal |
| Applications: | Immunohistochemistry, Paraffin, Western Blot |
| Reactivity: | Human |
| Format: | Liquid |
$329.00each
Catalog Number: LS-C188515-25
Catalog Number: LS-C188515
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- Description
- ER Beta antibody LS-C188515 is an unconjugated mouse monoclonal antibody to human ER Beta (ESR2) (aa493-504). Validated for IHC and WB.
- Application
- IHC-P, WB
- Reactivity
- Hu
- Intended Use
- Research Use Only
- Guarantees
- This antibody carries the LSBio 100% Guarantee. ✓
- Category
- Antibodies > Primary Antibodies > Monoclonal Antibodies
- Alternative Names
- ESTRB | ER Beta | ERbeta | ESR2 | ER-BETA | ESR-BETA | ESRB | Estrogen receptor 2 (ER beta) | NR3A2 | Estrogen receptor beta | Estrogen receptor beta 4
- UniProt Number
- Q92731
- NCBI GenBank
- NM_001437 | NP_001428.1
- SwissProt
- Q92731
Target
- Target
- Human ESR2 / ER Beta
- Antigen Species
- Human
- Epitope
- Recognizes human estrogen receptor beta 5 (ERB5), a splice variant of the nuclear receptor hormone ERbeta (ESR2), shown to exist in at least five isoforms (ERB1-ERB5). Although only the ERB1 variant appears fully functional, the remaining isoforms have been shown to form heterodimers with ERB1, thereby enhancing transcription. Immunohistochemical studies have revealed a ubiquitous expression of ERB5 in normal colorectal tissue, and to be present in all primary colorectal carcinomas studied. Studies also revealed the nuclear expression of ERB5 in the majority of breast carcinomas tested, with a possible association with improved patient survival.
- Gene Name
- ESR2
Antibody
- Host Species
- Mouse
- Clonality
- Monoclonal
- Clone
- 5/25
- Isotype
- IgG1
Immunogen
- Immunogen
- Tuberculin conjugated synthetic peptide LLSHVRHARYAP derived from the C-Terminus of human ERB5. Percent identity by BLAST analysis: Human (100%); Ferret (92%).
- Immunogen Type
- Synthetic Peptide (Linear)
Format
- Conjugate/Label
- Unconjugated
- Format
- Liquid
- Formulation
- PBS, 0.1% Sodium Azide
- Concentration
- 1 mg/mL
- Preservative
- Yes
- Purification Method
- Protein G Affinity
Storage & Handling
- Storage Conditions
- Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
- Recommended Storage Buffer
- PBS